… the developmental processes involved in prostate cancer … HGPIN as a significant predictor
for occurrence of prostate … key to understanding castrationresistant prostate cancer (CRPC). …

… 1 side, to HGPIN (formerly PIN3) and PCa emerging from it. A series … was involved with
the development and update of the … It is also called castration resistant prostate cancer (CRPCa) …

… prostate cancer. Citation1 This observation provided a rationale for ADT which aims to inhibit
growth of PC by suppressing serum testosterone to “castrate… wherein androgen precursors (…

… in high-grade prostatic intraepithelial neoplasia (HGPIN). Lesions … with metastatic
castration-resistant prostate cancer after … a precursor lesion it would be inappropriate to include it …

… to resemble human castrate-resistant prostate cancer. The … the plasma membrane in PC
development, this study aimed to … can progress to PC or HGPIN, being a PC precursor lesion [32,…

… the development of castration-resistant prostate cancer [11]. … step in progression from HGPIN
to invasive carcinoma. These … and “precursor-like” IDC-P share the same morphology, it is …

… , a precursor lesion PIN had developed, and the effect of … of aggressive castration-resistant
prostate cancer. Meanwhile, in the … in prostate cancer, compared with HGPIN, and in HGPIN, …

… with primary tumor development from both normal prostate and HGPIN lesions, mirroring …
precursor of intra-tumoral de novo androgen synthesis observed in the progression to castration…

… and metastatic castration resistant prostate cancer (mCRPC) … carcinomas in men with
biopsies that are positive for HGPIN … (PIP3) is converted from its diphosphate precursor by PI 3-…

… prostatic intraepithelial neoplasia (HGPIN) is the most common in situ precursor lesion of
prostate cancer… deprivation treatment or castration resistance in prostate cancer. Hereditary …