Implication of central nervous system barrier impairment in amyotrophic lateral sclerosis: gender-related difference in patients

H Alarcan, P Vourc'h, L Berton… - International Journal of …, 2023 - mdpi.com
… ) barrier impairment has been reported in amyotrophic lateral sclerosis (ALS), highlighting its
… The gender difference might guide the development of new drugs and help personalise the …

Sex and gender differences in Alzheimer's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis: A narrative review

A Nicoletti, R Baschi, CE Cicero, S Iacono… - Mechanisms of ageing …, 2023 - Elsevier
… considerable impact on health systems throughout the world. Alzheimer's disease (AD),
Parkinson's disease (PD) and Amyotrophic Lateral Sclerosis … Their impact will, therefore, become …

Gender-specific beneficial effects of docosahexaenoic acid dietary supplementation in G93A-SOD1 amyotrophic lateral sclerosis mice

P Torres, D Cacabelos, J Pairada, KC Bauer, J Boada… - …, 2020 - Springer
… cord (LSC) of amyotrophic lateral sclerosis (ALS) patients and … Also, beneficial effects on
cell viability were evidenced for the … study on the interaction of gender-influenced biological …

[HTML][HTML] The effects of diet and sex in amyotrophic lateral sclerosis

JA Pape, JH Grose - Revue neurologique, 2020 - Elsevier
… this time were only in one gender, more often males than females, potentially overshadowing
key findings and disease pathways that may only be present in one gender. As diet and …

Cardiovascular comorbidities in amyotrophic lateral sclerosis

M Pereira, M Gromicho, A Henriques… - Journal of the …, 2021 - Elsevier
… risk or protective effect in the development of ALS. Since the hypertension*gender interaction
was also significant (p = 0.013) gender can be considered to act as an effect modifier in the …

Gender-specific association of uric acid and survival in sporadic amyotrophic lateral sclerosis patients

J Bai, X Zhang, H Wang, W Yu, Z He, J Wang, M Li… - Brain Research, 2023 - Elsevier
… Our gender-specific results may be attributed to the effects of the oxidant-antioxidant …
different genders. In that case, it was female who are less vulnerable to the neurotoxic effect of UA …

Genetics and sex in the pathogenesis of amyotrophic lateral sclerosis (ALS): is there a link?

F Trojsi, G D'Alvano, S Bonavita… - International journal of …, 2020 - mdpi.com
… ”, “sex”, and “gender”. Further articles were included from … With regard to the effects of male
sex hormones on the ALS … that prenatal testosterone, irrespective of gender, might play a role …

Sex differences in amyotrophic lateral sclerosis survival and progression: a multidimensional analysis

M Grassano, C Moglia, F Palumbo… - Annals of …, 2024 - Wiley Online Library
… and multivariable mixed-effects regression models (MERs), with patients’ effect as random.
… the total effect of a factor (sex in our model) into direct and indirect effects: the indirect effect is …

Incidence of amyotrophic lateral sclerosis in Sardinia, Italy: age–sex interaction and spatial–temporal variability

G Borghero, V Pierri, R Vasta, T Ercoli… - Amyotrophic Lateral …, 2022 - Taylor & Francis
… (ALS) incidence in Sardinia, Italy, and the combined contribution of age and gender to
disease risk. We also checked disease incidence for spatial–temporal variability. Methods: ALS …

Brain–body mechanisms contribute to sexual dimorphism in amyotrophic lateral sclerosis

SM Jacob, S Lee, SH Kim, KA Sharkey… - Nature Reviews …, 2024 - nature.com
Gender might also affect the risk of developing ALS 17 : several environmental exposures, …
between genders, which might influence the susceptibility of an individual to ALS 19,20,21 . …