… Parental age at time of offspring conception is increasing in … sperm epigenetics, we next
considered relations of male age … mutated isoforms resulted in increased sperm motility 64 . Our …

… focus on the impact of delayed paternity on reproductive outcomes. Methods … semen quality
as well as the potential genetic and epigenetic shifts that accompany advancing paternal age…

… for confounders to allow adequate interpretation of the results; the studies of Boxmeer et
al. and Murphy et al. corrected for at least paternal age and smoking. It is important to take …

… linked with advanced paternal age due to the father’s sperm … The influence of paternal age
on reproductive outcomes has … , epigenetic changes associated with altered semen quality …

… between paternal age and decreased sperm quality and … harm fertility and reproductive
outcomes in middle-aged and … Some epigenetic factors appeared heritable and stable in …

… of poor sperm quality. As is well known, the genetic and epigenetic messages in gametes
are transmitted into offspring after fertilization [33, 34]. Sperm quality problems continue in …

… advanced paternal age may influence the epigenetic landscape of sperm cells, which can
have implications for fertility outcomes. … of paternal age on sperm quality and fertility outcomes. …

… , or due to epigenetic changes transmitted with gametes, we might expect the strongest …
shown that number of sperm and an index of sperm motility improve with age and then decline as …

… as parental age at the time of conception has been steadily … between sperm epigenetic
clocks and reproductive outcomes … semen quality in predicting couples’ reproductive outcomes. …

… effect of advanced paternal age on sperm chromatin integrity. Higher incidence of >10% DFI
in subjects aged ≥40 … : body weight affects hormonal balance and semen quality, the latter …