Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent
… To assess circadian gene expression in WT mice and the impact of circadian clock alterations
in mouse skeletal muscle, we analysed time-course microarray datasets derived from WT …
in mouse skeletal muscle, we analysed time-course microarray datasets derived from WT …
[HTML][HTML] Muscle atrophy phenotype gene expression during spaceflight is linked to a metabolic crosstalk in both the liver and the muscle in mice
… such as DNA repair, autophagy, and translation in the muscle. Our results … gene expression
in the liver and muscle atrophy gene expression are two paired events during spaceflight, for …
in the liver and muscle atrophy gene expression are two paired events during spaceflight, for …
Factors mediating spaceflight-induced skeletal muscle atrophy
… ), and IL-10 mRNA expression in skeletal muscle after 7-day bed … hindlimb immobilization
in mice lead to skeletal muscle atrophy … of mitochondrion-associated gene expression (157). …
in mice lead to skeletal muscle atrophy … of mitochondrion-associated gene expression (157). …
Transcriptome analysis of gravitational effects on mouse skeletal muscles under microgravity and artificial 1 g onboard environment
R Okada, S Fujita, R Suzuki, T Hayashi, H Tsubouchi… - Scientific reports, 2021 - nature.com
… These results suggested that gravitational change could affect the muscle’s gene expression
profile in mice under spaceflight for 35 days rather than other events, such as space …
profile in mice under spaceflight for 35 days rather than other events, such as space …
Inhibition of myostatin prevents microgravity-induced loss of skeletal muscle mass and strength
RC Smith, MS Cramer, PJ Mitchell, J Lucchesi… - PloS one, 2020 - journals.plos.org
… of prolonged spaceflight are known to result in skeletal muscle … -term microgravity-induced
muscle atrophy expected in mice … modulated gene expression in skeletal muscle concomitant …
muscle atrophy expected in mice … modulated gene expression in skeletal muscle concomitant …
Differential Gene Expression Analysis of Rodents Exposed to Long-Term Space Flight and Insights into Physiological Effects
J Oribello - 2021 - scholarworks.sjsu.edu
… In this project, differential gene expression analysis was … into the physiological effect of
space flight on skeletal muscle and … After adaptor removal, reads were mapped to the mouse …
space flight on skeletal muscle and … After adaptor removal, reads were mapped to the mouse …
Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight
… Most interest has been paid to the transcriptomic effects at the level of differential gene
expression (DGE). Recent transcriptome analyses of skeletal muscle in mice [19,20,21] have …
expression (DGE). Recent transcriptome analyses of skeletal muscle in mice [19,20,21] have …
Spaceflight induces changes in gene expression profiles linked to insulin and estrogen
… exerts its effects on most organs including the kidney and liver as well as skeletal muscle, …
signaling change during spaceflight we examined gene expression in mice that were flown …
signaling change during spaceflight we examined gene expression in mice that were flown …
Genetic diversity modulates the physical and transcriptomic response of skeletal muscle to simulated microgravity in male mice
… in-depth analysis of genetic expression has been performed. Here… A primary risk of spaceflight
is skeletal muscle deconditioning… mouse strain and SM was found for both skeletal muscle …
is skeletal muscle deconditioning… mouse strain and SM was found for both skeletal muscle …
Human skeletal muscle tissue chip autonomous payload reveals changes in fiber type and metabolic gene expression due to spaceflight
M Parafati, S Giza, TS Shenoy, JA Mojica-Santiago… - npj …, 2023 - nature.com
… muscle tissue chip platform provides an approach to studying the cell autonomous effects of
spaceflight on muscle … continued data collection from muscle tissue chip experimentation in …
spaceflight on muscle … continued data collection from muscle tissue chip experimentation in …