Efferocytosis in atherosclerosis

SS Adkar, NJ Leeper - Nature Reviews Cardiology, 2024 - nature.com
atherosclerosis is dysfunctional efferocytosis, a homeostatic … that can occur in the
atherosclerotic plaque and highlight the … mechanisms by which efferocytosis fails in …

Potential mechanisms and effects of efferocytosis in atherosclerosis

L Wang, H Li, Y Tang, P Yao - Frontiers in endocrinology, 2021 - frontiersin.org
… SMCs from the efferocytosis and then cause atheromatous plaque enlargement (Figure 2). …
Atherosclerotic lesions could gradually impair efferocytosis, while the defective efferocytosis

Mechanism of efferocytosis in atherosclerosis

LX Shu, L Cao, X Guo, ZB Wang, SZ Wang - Journal of Molecular Medicine, 2024 - Springer
… role in maintaining efferocytosis and preventing the development of atherosclerotic lesions.
… in vitro can correct the impaired efferocytosis caused by defective SR-BI in macrophages, …

Regulation of efferocytosis by caspase-dependent apoptotic cell death in atherosclerosis

A Tajbakhsh, PT Kovanen, M Rezaee, M Banach… - … International Journal of …, 2020 - Elsevier
… events in efferocytosis in the context of atherosclerosis. … mechanisms of apoptotic cell
death in atherosclerotic lesions is … or defective efferocytosis in the developing atherosclerotic

The intracellular signaling pathways governing macrophage activation and function in human atherosclerosis

HM Wilson - Biochemical Society Transactions, 2022 - portlandpress.com
… key epigenetic mechanism in the pathogenesis of atherosclerosis [44]… pathways in anti-inflammatory,
pro-resolving pathways can enhance efferocytosis within the atherosclerotic plaque

[HTML][HTML] Novel insight on the role of Macrophages in atherosclerosis: Focus on polarization, apoptosis and efferocytosis

Y Xie, H Chen, P Qu, X Qiao, L Guo, L Liu - International …, 2022 - Elsevier
… The MΦ in the atherosclerotic lesion is mainly composed of short-… the diversified regulatory
role and possible mechanisms of … So, defective efferocytosis and subsequent aggregation of …

Metabolic consequences of efferocytosis and its impact on atherosclerosis

A Yurdagul Jr - Immunometabolism, 2021 - journals.lww.com
… One mechanism of impaired efferocytosis in atherosclerosis … effects on atherosclerosis
caused by defective efferocytosis. … atherosclerotic lesions. When DCs are unable to carry out …

Efferocytosis of vascular cells in cardiovascular disease

JTO Cabrera, A Makino - Pharmacology & therapeutics, 2022 - Elsevier
… Therefore, we will not discuss the mechanisms of “apoptosis” … mechanisms for effective
clearance of apoptotic ECs and how defective efferocytosis of ECs can progress vascular disease

The regulation of efferocytosis signaling pathways and adipose tissue homeostasis in physiological conditions and obesity: Current understanding and treatment …

A Tajbakhsh, SM Gheibihayat, N Karami… - Obesity …, 2022 - Wiley Online Library
… molecular mechanisms to identify efferocytosis regulators in … of defective efferocytosis in
diseases such as atherosclerosis. … decreased necrosis in atherosclerotic plaque of Ldlr −/− mice. …

The Impaired Mechanism and Facilitated Therapies of Efferocytosis in Atherosclerosis

Z Wang, J Su, F Gong, L Xue, Z Su - Journal of Cardiovascular …, 2022 - journals.lww.com
efferocytosis is dysfunctional and superfluous ACs start to accumulate in the artery wall. Martinet
et al concluded that the level of efferocytosis in atherosclerosis … in atherosclerotic lesions