… drugs demonstrate no superior efficacy compared to Sorafenib [9]. … ARQ 092 is a small
allosteric pan-Akt inhibitor that showed … A combination of ARQ 092 with Sorafenib synergistically …

… efficacy of a new generation of allosteric AKT inhibitor, vevorisertib, alone or in combination
with sorafenib… To identify specific adverse effects related to the background of cirrhosis, we …

… Therefore, using an AKT inhibitor and a c-Met inhibitor might … could improve efficacy compared
with sorafenib alone. … positive results in cell models and animal models, and clinical trials …

… PI3K activates the lipid second messenger AKT. Afterward, … The inhibition of EGFR led to
increased efficacy of sorafenib. … Child–Pugh class B cirrhosis. The combination therapy was …

… Zebrafish is a well-known animal model for studying the … A cirrhosis were randomly allocated,
358 patients to sorafenib with … efficacy and toxicity relative to sorafenib in all the models. …

… in vitro, implying the relevance of AKT inhibition as an anti-… HK2 silencing synergized with
sorafenib to inhibit tumor growth of … de novo lipogenesis inhibitor improved the effectiveness of …

… To investigate the safety and antitumor effectiveness of the … , a cirrhotic rat model of HCC
was adopted to evaluate the interaction of SB with CR. The progression of HCC from cirrhosis is …

… validated the efficacy of Sorafenib, revealing … hepatic function (Child-Pugh A or B7), leaving
limited data for other patients. Cautionary use of sorafenib in patients with impaired hepatic …

… IL-6 inhibitor. In this study, NCTD ability to improve the Sora efficacy in thioacetamide (TAA)-…
of hepatic parenchyma and fibrosis percentage in liver tissue (P ≤ 0.001) (Fig 4A). …

… the efficacy of a treatment strategy involving either sorafenib … inhibitor, (SF + CQ), in
hepatocellular carcinoma rat model … H&E stained hepatic sections from control (N), hepatocellular …