[HTML][HTML] Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research

DS Quintana, A Lischke, S Grace, D Scheele… - Molecular …, 2021 - nature.com
… [74] measured CSF concentrations of oxytocin after intranasal administration of labeled (d5-…
87] measured cerebrospinal fluid samples before and after intranasal administration of 50 μg …

[HTML][HTML] Nasal oxytocin for the treatment of psychiatric disorders and pain: achieving meaningful brain concentrations

DC Yeomans, LR Hanson, DS Carson… - Translational …, 2021 - nature.com
… This study examined the brain distribution and dose–response of [ 125 I]-radiolabeled OT
after its intranasal administration to male Sprague-Dawley rats. This was done using …

[HTML][HTML] Effects of intranasal administration of oxytocin and vasopressin on social cognition and potential routes and mechanisms of action

S Yao, KM Kendrick - Pharmaceutics, 2022 - mdpi.com
… Overall, we conclude that while some functional effects of intranasal oxytocin and …
Increased concentrations of OXT in the cerebrospinal fluid (CSF) occur following intranasal

[HTML][HTML] Exploring associations between postpartum depression and oxytocin levels in cerebrospinal fluid, plasma and saliva

Q Chen, J Zhuang, R Zuo, H Zheng, J Dang… - Journal of Affective …, 2022 - Elsevier
… and downstream hormone levels. For example, the use of OXT nasal spray before the Trier
… 0.01), which can be explained in the following two aspects. Anatomically, some of the axons …

[HTML][HTML] Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques

MR Lee, TA Shnitko, SW Blue, AV Kaucher… - Nature …, 2020 - nature.com
cerebrospinal fluid (CSF) in monkeys when administered by IN and IV routes. In that study 6
, we sampled blood and CSF up to 1 hour (h) after … the high striatal d5OT concentration after

Changes in endogenous oxytocin levels after intranasal oxytocin treatment in adult men with autism: An exploratory study with long-term follow-up

K Alaerts, J Steyaert, B Vanaudenaerde… - European …, 2021 - Elsevier
… a self-perpetuating elevation of OT levels through a feed-forward triggering of its own release.
Within the current study, it was shown that higher levels of endogenous salivary OT at the …

pharmacokinetics of oxytocin administered intranasally to beef cattle

BK Wagner, AE Relling, JD Kieffer, LE Moraes… - Domestic Animal …, 2020 - Elsevier
oxytocin and vasopressin intranasally increased concentrations in plasma and cerebral spinal
fluid … T MAX of 3.5 min after intranasal dose administration. An average T 1/2 of 12.1 min …

[HTML][HTML] Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans

DA Martins, N Mazibuko, F Zelaya… - Nature …, 2020 - nature.com
… methods of intranasal administration (a standard nasal spray, … postulates that OT reaches
the cerebrospinal fluid (CSF) and … following intranasal administration (using either a standard …

[HTML][HTML] Sniffing oxytocin: Nose to brain or nose to blood?

S Yao, Y Chen, Q Zhuang, Y Zhang, C Lan, S Zhu… - Molecular …, 2023 - nature.com
… administration route inspired by findings that neuropeptides could enter the cerebrospinal
fluid as … in plasma OXT concentrations following a single dose of intranasal 24 IU OXT either …

[HTML][HTML] In the nose or on the tongue? Contrasting motivational effects of oral and intranasal oxytocin on arousal and reward during social processing

J Kou, C Lan, Y Zhang, Q Wang, F Zhou, Z Zhao… - Translational …, 2021 - nature.com
blood OT concentrations following the oral and intranasal treatments were broadly similar,
although concentrations were higher following the intranasal dose… While it is possible that this …