The understanding of Parkinson's disease through genetics and new therapies

O Uwishema, H Onyeaka, R Badri, AN Yücel… - Brain and …, 2022 - Wiley Online Library
… , is currently being studied for new therapies. This article focuses on history, mechanism,
factors causing Parkinson's disease as well as future therapies for the cure of the diseases. …

[HTML][HTML] Caffeine and Parkinson's disease: multiple benefits and emerging mechanisms

X Ren, JF Chen - Frontiers in Neuroscience, 2020 - frontiersin.org
Parkinsons disease is primarily characterized by cardinal motor symptoms but cognitive
changes also occur both in the early and later stages of the disease process. In fact, ∼30% of …

[HTML][HTML] The emerging role of probiotics in neurodegenerative diseases: new hope for Parkinson's disease?

V Castelli, M d'Angelo, M Quintiliani… - Neural Regeneration …, 2021 - journals.lww.com
… use of probiotics for Parkinsons disease prevention or treatment or as adjuvant therapy, …
Future investigations in Parkinsons disease should consider the role of the gut-brain axis …

Advancement in the modelling and therapeutics of Parkinson's disease

SN Rai, P Singh - Journal of chemical neuroanatomy, 2020 - Elsevier
… have helped to recognize specific events, animal models, both toxic and genetic, have
replicated almost all of the hallmarks of PD and are very helpful for testing and finding new

[HTML][HTML] Strategies for the treatment of Parkinson's disease: beyond dopamine

A Iarkov, GE Barreto, JA Grizzell… - Frontiers in aging …, 2020 - frontiersin.org
… well as new and prospective therapies for the disease. The current data suggest that prevention
or early treatment of PD may be the most effective therapeutic strategy. New advances in …

[HTML][HTML] Genetic predispositions of Parkinson's disease revealed in patient-derived brain cells

J Tran, H Anastacio, C Bardy - NPJ Parkinson's disease, 2020 - nature.com
disorder and has been the focus of intense investigations to understand its etiology and
progression, but it still lacks a cure. Modeling diseases … and validation of new treatments. Here, …

[HTML][HTML] Multifunctional role of natural products for the treatment of Parkinson's disease: at a glance

MM Rahman, X Wang, MR Islam, S Akash… - Frontiers in …, 2022 - frontiersin.org
… characterize the currently available medications for Parkinsons and their therapeutic effects…
the future to treat PD in new ways or as supplements to existing treatments. We looked at the …

[HTML][HTML] Targeting oxidative stress mechanisms to treat Alzheimer's and Parkinson's disease: a critical review

…, P Shah, R Yarlagadda, S Ahmad… - … medicine and cellular …, 2022 - ncbi.nlm.nih.gov
… There will also be an examination of present and upcoming treatments for oxidative stress.
For these new medicines, future outlooks are presented to discuss their possibility for disease-…

Emerging neuroprotective effect of metformin in Parkinson's disease: A molecular crosstalk

YN Paudel, E Angelopoulou, C Piperi, MF Shaikh… - Pharmacological …, 2020 - Elsevier
… in several neurodegenerative disorders including PD, both in vitro and in vivo. In this review,
we explore the neuroprotective potential of metformin based on emerging evidence from pre…

Fluorescent probes for bioimaging of potential biomarkers in Parkinson's disease

L Gao, W Wang, X Wang, F Yang, L Xie… - Chemical Society …, 2021 - pubs.rsc.org
… of new fluorescent probes that can be used clinically in the early diagnosis of PD and
contributes to the development of efficient PD drugs in … of new drugs to inhibit α-syn aggregation. …