[HTML][HTML] Mechanisms and markers of resistance to androgen signaling inhibitors in patients with metastatic castration-resistant prostate cancer
A Csizmarik, B Hadaschik, G Kramer, P Nyirady… - … oncology: seminars and …, 2021 - Elsevier
… most important androgen receptor dependent and independent resistance mechanisms and
pay … In the last few years, several new therapies with various mechanism of action became …
pay … In the last few years, several new therapies with various mechanism of action became …
Mechanisms of resistance to second-generation antiandrogen therapy for prostate cancer: actual knowledge and perspectives
F Pinto, F Dibitetto, M Ragonese, P Bassi - Medical Sciences, 2022 - mdpi.com
… previously found to convert the androgen receptor antagonist enzalutamide to an androgen
… new mechanism could lead to a new way of labeling castration-resistant prostate cancer: in …
… new mechanism could lead to a new way of labeling castration-resistant prostate cancer: in …
Androgen receptor-dependent mechanisms mediating drug resistance in prostate cancer
M Ehsani, FO David, A Baniahmad - Cancers, 2021 - mdpi.com
… mechanisms leading to therapy resistance against ADT and antagonists and AR bypass
mechanisms as … A new development to identify AR antagonists that target AR NTD is another …
mechanisms as … A new development to identify AR antagonists that target AR NTD is another …
[HTML][HTML] Dysregulated androgen synthesis and anti-androgen resistance in advanced prostate cancer
CM Armstrong, AC Gao - American Journal of Clinical and …, 2021 - ncbi.nlm.nih.gov
… new knowledge and explore better treatments for cancer. … androgen receptor mutants
obtained by random amino acid substitution of H874 and mutation hot spot T877 in prostate cancer…
obtained by random amino acid substitution of H874 and mutation hot spot T877 in prostate cancer…
Mechanisms of enzalutamide resistance in castration‐resistant prostate cancer and therapeutic strategies to overcome it
Y Wang, J Chen, Z Wu, W Ding, S Gao… - British journal of …, 2021 - Wiley Online Library
… androgen receptor antagonist approved by the Food and Drug Administration to treat
patients with castration-resistant prostate cancer. … In conclusion, these emerging mechanisms …
patients with castration-resistant prostate cancer. … In conclusion, these emerging mechanisms …
Resistance to second-generation androgen receptor antagonists in prostate cancer
KT Schmidt, ADR Huitema, CH Chau… - Nature Reviews …, 2021 - nature.com
… The introduction of second-generation androgen receptor antagonists (SG-ARAs) has
greatly impacted the treatment of metastatic prostate cancer, providing tolerable and efficacious …
greatly impacted the treatment of metastatic prostate cancer, providing tolerable and efficacious …
[HTML][HTML] Metabolic reprogramming as an emerging mechanism of resistance to endocrine therapies in prostate cancer
P Chetta, G Zadra - Cancer Drug Resistance, 2021 - ncbi.nlm.nih.gov
… Prostate cancer (PCa) is the second leading cause of cancer-related death in the US. Androgen
receptor (AR) … -generation inhibitors of AR signaling in the metastatic setting, resistance …
receptor (AR) … -generation inhibitors of AR signaling in the metastatic setting, resistance …
Recent discoveries in the androgen receptor pathway in castration-resistant prostate cancer
D Obinata, MG Lawrence, K Takayama, N Choo… - Frontiers in …, 2020 - frontiersin.org
… new tools to validate and prioritize candidate treatments for clinical trials. In this review, we
examine mechanisms of castration-resistance involving the AR and collaborating TFs, new …
examine mechanisms of castration-resistance involving the AR and collaborating TFs, new …
Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment
… This suggests that development of new therapies that can … characteristic mechanisms of
enzalutamide-resistance, such … at inhibiting growth of enzalutamide-resistant prostate cancer …
enzalutamide-resistance, such … at inhibiting growth of enzalutamide-resistant prostate cancer …
Anti-androgen receptor therapies in prostate cancer: a brief update and perspective
J Huang, B Lin, B Li - Frontiers in Oncology, 2022 - frontiersin.org
… cancer cells recently emerged as a realistic solution for a potentially curable result. … anti-AR
treatment resistance, we hypothesized that eliminating AR protein from prostate cancer cells …
treatment resistance, we hypothesized that eliminating AR protein from prostate cancer cells …