… most important androgen receptor dependent and independent resistance mechanisms and
pay … In the last few years, several new therapies with various mechanism of action became …

… previously found to convert the androgen receptor antagonist enzalutamide to an androgen
… new mechanism could lead to a new way of labeling castration-resistant prostate cancer: in …

… mechanisms leading to therapy resistance against ADT and antagonists and AR bypass
mechanisms as … A new development to identify AR antagonists that target AR NTD is another …

… new knowledge and explore better treatments for cancer. … androgen receptor mutants
obtained by random amino acid substitution of H874 and mutation hot spot T877 in prostate cancer…

… androgen receptor antagonist approved by the Food and Drug Administration to treat
patients with castration-resistant prostate cancer. … In conclusion, these emerging mechanisms …

… The introduction of second-generation androgen receptor antagonists (SG-ARAs) has
greatly impacted the treatment of metastatic prostate cancer, providing tolerable and efficacious …

… Prostate cancer (PCa) is the second leading cause of cancer-related death in the US. Androgen
receptor (AR) … -generation inhibitors of AR signaling in the metastatic setting, resistance …

… new tools to validate and prioritize candidate treatments for clinical trials. In this review, we
examine mechanisms of castration-resistance involving the AR and collaborating TFs, new …

… This suggests that development of new therapies that can … characteristic mechanisms of
enzalutamide-resistance, such … at inhibiting growth of enzalutamide-resistant prostate cancer …

… cancer cells recently emerged as a realistic solution for a potentially curable result. … anti-AR
treatment resistance, we hypothesized that eliminating AR protein from prostate cancer cells …