Cell-penetrating peptides: Emerging tools for mRNA delivery

H Yokoo, M Oba, S Uchida - Pharmaceutics, 2021 - mdpi.com
Peptide-based nanoparticles can be easily synthesized in a single-… achieved by post-conjugation
of CPP to nanoparticles [50]. … PPx/GALA modulated the endocytosis pathway in DCs to …

[HTML][HTML] Peptide-based delivery of therapeutics in cancer treatment

T Samec, J Boulos, S Gilmore, A Hazelton… - Materials Today Bio, 2022 - Elsevier
cell receptors that bind to proteins in the extracellular matrix [74]. … -conjugated nanoparticles
and cell penetrating peptide … delivery, pinocytosis and clathrin-mediated endocytosis are …

[HTML][HTML] Exploration and insights into the cellular internalization and intracellular fate of amphiphilic polymeric nanocarriers

S Mazumdar, D Chitkara, A Mittal - Acta Pharmaceutica Sinica B, 2021 - Elsevier
nanoparticles with cell membrane plays a crucial role in endocytosis and intracellular trafficking
amphiphilic Janus nanoparticles comprising of octadecanethiol conjugated cationic silica …

Peptide-conjugated nano delivery systems for therapy and diagnosis of cancer

I Gaurav, X Wang, A Thakur, A Iyaswamy, S Thakur… - Pharmaceutics, 2021 - mdpi.com
… charged or neutral peptides on gold nanoparticles (AuNPs) … through receptor-based
endocytosis. Research reported that … arginine-rich cell-penetrating peptide-modified exosomes for …

Progress in tumour-targeted drug delivery based on cell-penetrating peptides

X Kong, J Xu, X Yang, Y Zhai, J Ji… - Journal of Drug Targeting, 2022 - Taylor & Francis
… may enter the cell through the endocytic pathway, which … charged CPP-based nanoparticle
and loaded negatively … endothelial cells in the CNS, restricting the transportation of …

Cell-penetrating peptides in diagnosis and treatment of human diseases: from preclinical research to clinical application

J Xie, Y Bi, H Zhang, S Dong, L Teng, RJ Lee… - Frontiers in …, 2020 - frontiersin.org
… by the classical endocytosis pathway. However, several … absorption onto the nanoparticles
surface to generate BBB … were conjugated by MMP-2/-9 cleaved peptide linker. Cy5-…

Applications of amphipathic and cationic cyclic cell-penetrating peptides: Significant therapeutic delivery tool

MI Sajid, M Moazzam, R Stueber, SE Park, Y Cho… - Peptides, 2021 - Elsevier
… the cellular penetration by cyclic [KW] 5 -capped nanoparticles … permeates the cells dominantly
through endocytosis, … -TP conjugates delivered active TP into TP-deficient cells in vitro in …

Highlights on cell-penetrating peptides and polymer-lipid hybrid nanoparticle: Overview and therapeutic applications for targeted anticancer therapy

PD Bangera, DD Kara, K Tanvi, VK Tippavajhala… - AAPS …, 2023 - Springer
… -penetrating peptides (CPPs) which transport cargo (ability to … cells via endocytosis and an
increased ability to kill cancerous cells due to the conjugation of the cell-penetrating peptide, c…

Brain penetrating peptides and peptide–drug conjugates to overcome the blood–brain barrier and target CNS diseases

X Zhou, QR Smith, X Liu - Wiley Interdisciplinary Reviews …, 2021 - Wiley Online Library
… (LDLR) mediates the endocytosis of cholesterol-rich low-… THR peptide has been conjugated
with gold nanoparticles (… transitions of the cell penetrating peptide transportan 10 in the …

Combination of cell-penetrating peptides with nanomaterials for the potential therapeutics of central nervous system disorders: a review

Y Zhang, P Guo, Z Ma, P Lu, D Kebebe… - Journal of …, 2021 - Springer
… An accepted mechanism of specific CPPs is endocytosis [16]. However, the … : cell penetrating
peptides, the conjugates of CPPs and drug/gene, and CPPs modified nanoparticles were …