[HTML][HTML] Internalization mechanisms of cell-penetrating peptides

I Ruseska, A Zimmer - Beilstein journal of nanotechnology, 2020 - beilstein-journals.org
Endocytosis as a mechanism for the transport of CPPs … the endocytic mechanisms used by
each CPP conjugate … The future fate of these structures is not entirely clear. Viruses are known …

[HTML][HTML] Cell-penetrating peptide-based delivery of macromolecular drugs: Development, strategies, and progress

Z Sun, J Huang, Z Fishelson, C Wang, S Zhang - Biomedicines, 2023 - mdpi.com
… It covers more than 1600 peptide-conjugated drug molecules… These energy-dependent
endocytic pathways transport most … Consequently, effective EV-based intracellular delivery of an …

[HTML][HTML] An update on cell-penetrating peptides with intracellular organelle targeting

CP Cerrato, Ü Langel - Expert Opinion on Drug Delivery, 2022 - Taylor & Francis
… with cells and whether particles were internalized in an endocytic or nonendocytic manner.
In any case, the transport of the virus particle to the cellconjugates (mitFects) for intracellular

[HTML][HTML] In vitro assays: friends or foes of cell-penetrating peptides

J Liu, S Afshar - International Journal of Molecular Sciences, 2020 - mdpi.com
… such as endocytic vesicles [17]. The fluorescent dyes and biotin, conjugated to CPPs, do not
… In the event of OxDex-CPP conjugates entering the intracellular domain, OxDex would bind …

Cell-penetrating peptide-conjugated lipid/polymer hybrid nanovesicles for endoplasmic reticulum-targeting intracellular delivery

JY Kang, S Kim, J Kim, NG Kang, CS Yang… - Journal of Materials …, 2021 - pubs.rsc.org
… to the plasma membrane through vesicle trafficking, enabling post-… -PEO induced ATP-dependent
endocytosis. These observations … Subsequent fate of the LPNV Pnt is unknown, but we …

[HTML][HTML] Nanoparticles modified with cell-penetrating peptides: Conjugation mechanisms, physicochemical properties, and application in cancer diagnosis and …

I Gessner, I Neundorf - International journal of molecular sciences, 2020 - mdpi.com
… versatile vehicles for the intracellular transport of various cargos, … On the other hand,
endocytosis is mainly observed when larger … fate of conjugates in comparison to their individual …

Cell-penetrating peptides

M Zorko, Ü Langel - Cell penetrating peptides: methods and protocols, 2022 - Springer
… into the cells, where direct and endocytic internalization of … , uptake, intracellular trafficking
and siRNA uptake [32]. In … [104], dual peptide conjugation strategy of a mitochondrial targeting …

[HTML][HTML] Redesigning of cell-penetrating peptides to improve their efficacy as a drug delivery system

I Szabó, M Yousef, D Soltész, C Bató, G Mező… - Pharmaceutics, 2022 - mdpi.com
… for the transport of a broad range of compounds into cells. … its conjugated cargo, they
can induce one or more endocytic … escape of CPP-based conjugates. Both strategies were …

… the Impact of Payload Conjugation on the Cell-Penetrating Efficiency of the Endosomal Escape Peptide dfTAT: Implications for Future Designs for CPP-Based …

J Diaz, M Pietsch, M Davila, G Jaimes… - Bioconjugate …, 2023 - ACS Publications
… AF488-H1 if its trafficking in the endocytic pathway is different from … of cell-penetrating peptides
(CPPs), specifically how the … This intracellular trafficking pathway appeared consistent for …

[HTML][HTML] Transportan peptide stimulates the nanomaterial internalization into mammalian cells in the bystander manner through macropinocytosis

YX Li, Y Wei, R Zhong, L Li, HB Pang - Pharmaceutics, 2021 - mdpi.com
cell-penetrating peptides (CPPs). CPPs are a family of short … To confirm the intracellular
trafficking of the endocytosed NPs… chemically conjugate CPPs with NPs to invoke endocytosis