… of the proposed endogenous ligands for … of clonidine-like drugs. Moxonidine and rilmenidine
have better therapeutic profiles (fewer side effects) than clonidine as antihypertensive drugs…

… Moreover, endogenous β-carbolines might somehow affect the metabolism of … β-carboline
alkaloids in soy sauce, which are inhibitors of MAO. Based on concentration, other substances …

… Moreover, endogenous β-carbolines might somehow affect the … , environmental, and
endogenous β-carboline alkaloids in … of classical clonidine-displacing substance. Biochemistry …

… Beyond complex interactions with receptor systems, β-carbolines … Natural products rich
in βcarbolines have been used … [113], it was reported that the behavior of an endogenous …

… Inverse agonists, such as the β-carbolines, exert an … as endogenous substances capable
of binding to opiate receptors12,13 generated an interest to search for possible endogenous …

… Presence of other drugs: Concurrent administration of two or more drugs may … drugs. the
Toxins total body which water accumulate can increase can displace which increases drugs …

… -β-carboline… Clonidine was patented in 1961 approved and came to market in 1966. It is
an anti-hypertensive medicine with a clear-cut central site of act. The pharmacology of clonidine …

… In uraemia, the total body water can increase which increases Vd of small water-soluble
drugs. Toxins which accumulate can displace drugs from plasma protein binding sites …

… plays a significant role in both approved synthetic drugs and those currently in clinical trials,
it … However, this thesis will focus on the discussion of the ‘simple’ β-carbolines referred to as …

… modifications made to ethyl B-carboline-3-carboxylate (B-… endogenous substances capable
of binding to opiate receptors12, 13 generated an interest to search for possible endogenous …