Gap junctional intercellular communication as a method to detect and predict carcinogenicity

V Krutovskikh, H Yamasaki - Carcinogenicity, 2021 - taylorfrancis.com
Endogenous and exogenous modulation of gap junctional intercellular communication:
toxicological and pharmacological implications. Life Sci 1993; 53:1-19. Wade MH, Trosko JE, …

Connexin and gap junctions: perspectives from biology to nanotechnology based therapeutics

S Jindal, S Chockalingam, SS Ghosh… - Translational …, 2021 - Elsevier
… The concept of gap junctions and their role in intercellular communication has been known
… biology of connexins in mediating gap junction intercellular communication (GJIC) and their …

A role of connexin 43 on the drug-induced liver, kidney, and gastrointestinal tract toxicity with associated signaling pathways

R Katturajan, SE Prince - Life sciences, 2021 - Elsevier
… through gap junction intercellular communication, regulating … , by excusing endogenous
and exogenous wastes from our … through modulation of intercellular gap junction with targeting …

Brain Disorders and Chemical Pollutants: A Gap Junction Link?

M Mesnil, N Defamie, C Naus, D Sarrouilhe - Biomolecules, 2020 - mdpi.com
… While Cx43 is a negative modulator of neuronal … is now largely banned due to its toxicity.
In the environment, lindane … activated by both endogenous and exogenous ligands including …

Gap junctions and connexins in microglia-related oxidative stress and neuroinflammation: perspectives for drug discovery

G Caruso, L Di Pietro, F Caraci - Biomolecules, 2023 - mdpi.com
… We will then discuss how pharmacological modulation of … N-acetylcysteine, can modulate
the activity of connexins and … given by exogenous (eg, bacterial infection) or endogenous (eg…

Gap junction-dependent and-independent functions of Connexin43 in biology

Y Zhu - Biology, 2022 - mdpi.com
… [15], and gap junction-modulating molecules as potential … It is worth noting that the identity
of the endogenous Cx43 … Where does this toxicity come from? This question may even …

Role and posttranslational regulation of Cx46 hemichannels and gap junction channels in the eye lens

MA Retamal, GA Altenberg - Frontiers in Physiology, 2022 - frontiersin.org
… form hemichannels and gap junction channels that … gap junction channels in the lens under
physiological conditions and in the formation of cataracts, with emphasis on the modulation

A cellular assay for the identification and characterization of connexin gap junction modulators

A Danish, R Gedschold, S Hinz, AC Schiedel… - International Journal of …, 2021 - mdpi.com
Gap junctional intercellular communication regulates … performed to analyze endogenous
Cx43 expression in HeLa … to be not due to cell toxicity as evidenced by its results in an MTT …

Exogenous adenosine antagonizes excitatory amino acid toxicity in primary astrocytes

Y Liu, S Chu, Y Hu, S Yang, X Li, Q Zheng, Q Ai… - Cellular and Molecular …, 2021 - Springer
gap junction protein (Cx43) and reduce glutamate diffusion. Inhibition of A2aR attenuated
adenosine inhibition of gap junction intercellular communication … Adenosine is an endogenous

GAP junctions: multifaceted regulators of neuronal differentiation

S Talukdar, L Emdad, SK Das, PB Fisher - Tissue Barriers, 2022 - Taylor & Francis
… barrier (BBB) to the modulation of integrative brain functions (ie, … in vivo astrocyte-mediated
toxicity. Citation143 Blocking GJs … is induced mainly by the exogenous expression of lineage-…