Hypoglycaemia aggravates impaired endothelial-dependent vasodilation in diabetes by suppressing endothelial nitric oxide synthase activity and stimulating …

A He, Y Guo, Z Xu, J Yan, L Xie, Y Li, D Lv… - Microvascular Research, 2023 - Elsevier
During the process of endothelial dysfunction under hypoglycaemia in diabetes, … and
compromise therapeutic effect of hypoglycaemic therapy, a predominant form of diabetes treatment …

[PDF][PDF] The emerging role of endothelial cells in the pathogenesis of thoracic aortic aneurysm and dissection

A Verstraeten, I Fedoryshchenko… - European Heart …, 2023 - academic.oup.com
Endothelial dysfunction and compromised eNOS/Akt signaling in the thoracic aorta
during the progression of Marfan syndrome. Br J Pharmacol 2007;150:1075–1083. https://doi.org/10. …

[HTML][HTML] Endothelial nitric oxide synthase in the perivascular adipose tissue

AWC Man, Y Zhou, N Xia, H Li - Biomedicines, 2022 - mdpi.com
… AMPK/eNOS pathway in PVAT is responsible for its anticontractile function. Treating PVAT …
adipose tissue accelerates obesity-induced endothelial dysfunction. In Proceedings of the 1st …

[HTML][HTML] Pathophysiology and therapeutics of thoracic aortic aneurysm in Marfan syndrome

K Asano, A Cantalupo, L Sedes, F Ramirez - Biomolecules, 2022 - mdpi.com
… major cellular and molecular determinants of thoracic aortic disease. In spite of … endothelial
dysfunction and improper angiotensin II and TGFβ signaling in driving thoracic aortic disease …

[HTML][HTML] Endothelial dysfunction in Marfan syndrome mice is restored by resveratrol

A Mieremet, M van der Stoel, S Li, E Coskun… - Scientific reports, 2022 - nature.com
… As prolonged TGF-β signaling has been associated with endothelial dysfunction 62 , this …
during development in a zebrafish model with induced compromised focal adhesion function, …

[HTML][HTML] Pleiotropic activation of endothelial function by angiotensin II receptor blockers is crucial to their protective anti-vascular remodeling effects

AY Tehrani, Z White, LW Tung, RRY Zhao, N Milad… - Scientific reports, 2022 - nature.com
… of major class effects on NO-dependent endothelial function independently of their capacity
of blocking classic AngII/AT1R signaling and associated oxidative stress, resulting in a …

[HTML][HTML] The role of inflammation and myeloperoxidase-related oxidative stress in the pathogenesis of genetically triggered thoracic aortic aneurysms

C Malecki, BD Hambly, RW Jeremy… - International Journal of …, 2020 - mdpi.com
… of matrix metalloproteinases, induction of endothelial dysfunction and vascular smooth
muscle cell phenotypic switching, and activation of ERK1/2 signaling. The weight of evidence …

[HTML][HTML] Inhibition of endoplasmic reticulum stress improves acetylcholine-mediated relaxation in the aorta of type-2 diabetic rats

S Mustapha, AK Azemi, WAN Wan Ahmad… - Molecules, 2022 - mdpi.com
endothelial function was impaired in diabetes, however, supplementation with TUDCA improved
the function via eNOS/Akt… the endothelium, which compromises endothelial function by …

Increase of PCSK9 expression in diabetes promotes VEGFR2 ubiquitination to inhibit endothelial function and skin wound healing

JJ Gao, FY Wu, YJ Liu, L Li, YJ Lin, YT Kang… - Science China Life …, 2024 - Springer
… The vascular endothelial growth factor (VEGF) signaling pathway was considerably …
However, only the association between NEDD4 and VEGFR2 was weakened after PCSK9 …

Aortic regurgitation is associated with ascending aortic remodeling in the nondilated aorta

B Balint, JM Federspiel, T Schwab… - … , and vascular biology, 2021 - Am Heart Assoc
… , we evaluated the signal intensity of fibrillin and collagen in all 3 layers of the … endothelial
dysfunction in the aortic wall. We recently reported that altered eNOS expression in BAV aortas