[HTML][HTML] Metabolic regulation and dysregulation of endothelial small conductance calcium activated potassium channels

S Kant, F Sellke, J Feng - European Journal of Cell Biology, 2022 - Elsevier
… of calcium-activated potassium channels in endothelial function, … IK channels that are most
heavily implicated in endothelium-… produce endothelial and smooth muscle hyperpolarization

Endothelium-dependent hyperpolarization: the evolution of myoendothelial microdomains

CJ Garland, KA Dora - Journal of Cardiovascular Pharmacology, 2021 - journals.lww.com
… of signaling proteins to regulate both hyperpolarization and NO release. So, … potassium
channels were actually located on ECs. That K Ca 2.3 and K Ca 3.1 are located on endothelial

[HTML][HTML] Hyperpolarization and the endothelium

CJ Garland, KA Dora - Current Opinion in Physiology, 2023 - Elsevier
… However, K + efflux through these endothelial channels does … , with formation regulated
by plasminogen activator inhibitor-… structure, the complement of ion channels on the ECs and …

Endothelial KCa1.1 and KCa3.1 channels mediate rat intrarenal artery endothelium‐derived hyperpolarization response

E Pinilla, A Sánchez, MP Martínez, M Muñoz… - Acta …, 2021 - Wiley Online Library
… limitations such as changes in ion channel expression compared to their physiological state.
… Therefore, we cannot rule out the involvement of VSMC K Ca 1.1 channels via activation by …

Endothelial ion channels and cell-cell communication in the microcirculation

WF Jackson - Frontiers in Physiology, 2022 - frontiersin.org
… , endothelial cell ion channels play a central role in cell-cell communication and regulation
cell [Ca 2+ ] in , activation of IK Ca and SK Ca channels to hyperpolarize the endothelial cells, …

Role of Protein Kinase C in Metabolic Regulation of Coronary Endothelial Small Conductance Calcium‐Activated Potassium Channels

H Xing, SA Sabe, G Shi, DD Harris, Y Liu… - Journal of the …, 2024 - Am Heart Assoc
… coronary endothelial SK channels are metabolically regulated, and how this regulation
Activation of SK channels leads to the hyperpolarization of the endothelial cells and evokes …

Endothelial ATP-sensitive potassium channel protects against the development of hypertension and atherosclerosis

Y Li, Q Aziz, N Anderson, L Ojake, A Tinker - Hypertension, 2020 - Am Heart Assoc
… possible contribution of endothelial Kir6.1 in BP regulation, we … ) mice suggesting K ATP
channels in the endothelium do not … direct propagation of endothelial cell hyperpolarization via …

Endothelial signaling at the core of neurovascular coupling: The emerging role of endothelial inward-rectifier K+ (Kir2. 1) channels and N-methyl-d-aspartate receptors …

S Negri, P Faris, T Soda, F Moccia - … journal of biochemistry & cell biology, 2021 - Elsevier
Endothelium-dependent hyperpolarization is then preferentially propagated to upstream
vessels by connexins-based gap junctions to mediate arteriolar dilation and cause an increase …

Potassium (K+) channels in the pulmonary vasculature: Implications in pulmonary hypertension Physiological, pathophysiological and pharmacological regulation

G Mondéjar-Parreño, A Cogolludo… - Pharmacology & …, 2021 - Elsevier
K + channels are also expressed in pulmonary artery endothelial cells (PAEC) where they
control resting Em, Ca 2+ entry and the … endothelium-dependent hyperpolarizing factor …

Negative Influence by the Force: Mechanically Induced Hyperpolarization via K2P Background Potassium Channels

M Lengyel, P Enyedi, G Czirják - International Journal of Molecular …, 2021 - mdpi.com
… Therefore, the regulatory properties of the … the endothelium-dependent flow-induced
vasodilation mechanism, the activation of TREK channels by the shear stress of the endothelial cells …