[HTML][HTML] Oxygen homeostasis and cardiovascular disease: A role for HIF?

X Li, Q Zhang, MI Nasser, L Xu, X Zhang, P Zhu… - Biomedicine & …, 2020 - Elsevier
… -1 can regulate the adaptive cellular responses to hypoxia by … of pulmonary arterial endothelial
cells causes vascular … reduced intimal proliferation and down-regulation of E-selectin and …

CircRNA–miRNA interactions in atherogenesis

KL Tong, KE Tan, YY Lim, XY Tien, PF Wong - Molecular and cellular …, 2022 - Springer
… One of the most common mechanism of action of circRNAs … The vascular endothelium acts
as a barrier between … species (ROS), endothelin-1 (ET-1), and cell adhesion molecule (CAM) …

Endothelial to mesenchymal transition in kidney fibrosis

ME Jacobs, DK de Vries, MA Engelse… - Nephrology Dialysis …, 2024 - academic.oup.com
… of tissue hypoxia. In renal disease, incomplete recovery … the binding of ET1 ligand to endothelin
receptor type B on RECs [40]. ET… in monocrotaline-induced kidney injury in rats [52]. This …

Aldosterone: essential for life but damaging to the vascular endothelium

M Crompton, LJ Skinner, SC Satchell, MJ Butler - Biomolecules, 2023 - mdpi.com
Down regulation of 11 β-HSD2 was also linked with salt … in the cell membrane fractions
from Wistar rats and human … that widespread use of endothelin receptor antagonists may be …

The dual roles of autophagy and the GPCRs-mediating autophagy signaling pathway after cerebral ischemic stroke

W Hou, Y Hao, L Sun, Y Zhao, X Zheng, L Song - Molecular Brain, 2022 - Springer
… of a variety of hypoxia-responsive genes, such as vascular endothelial growth factor, … infarct
volume in rats exposed to transient focal cerebral ischemia [70]. Down-regulation of beclin-1 …

Hypoxia-inducible factors not only regulate but also are myeloid-cell treatment targets

L Kling, A Schreiber, KU Eckardt… - Journal of leukocyte …, 2021 - academic.oup.com
… B scavenger receptor CD36 and its ligand thrombospondin-1 … , combined PHD down-regulation
and up-regulation of HIF … Subsequently, endothelin receptor stimulation activated …

Effects of thyroid hormone on tissue hypoxia: relevance to sepsis therapy

AI Lourbopoulos, IS Mourouzis, AG Trikas… - Journal of Clinical …, 2021 - mdpi.com
… vivo and in vitro via vascular endothelial growth factor A (VEGF… percentage of injured
mitochondria, and down-regulation of … Ligand-bound TRα on macrophages protected the kidney, …

[HTML][HTML] The driving mechanism and targeting value of mimicry between vascular endothelial cells and tumor cells in tumor progression

X Ma, Z Geng, S Wang, Z Yu, T Liu, S Guan… - Biomedicine & …, 2023 - Elsevier
… pathways, thus inhibiting the endothelin receptor type A/GSK-3β/… , resulting in down-regulation
of vascular endothelial (VE)-… focuses on describing the effects of GCS and hypoxia on VM. …

Epigenetic regulation of endothelial dysfunction and inflammation in pulmonary arterial hypertension

J Hudson, L Farkas - International journal of molecular sciences, 2021 - mdpi.com
… expressed eNOS gene in the vascular endothelium [33]. In … two classes of ligands that
are detected by host cells through a … Hypoxia signaling is mediated via the hypoxia-inducible …

[HTML][HTML] Molecular mechanisms of endothelial remodeling under doxorubicin treatment

E Podyacheva, M Danilchuk, Y Toropova - Biomedicine & …, 2023 - Elsevier
… by inhibiting the expression of vascular endothelium (VE)-cadherin … physical environmental
factors, such as hypoxia, oxidative stress, … These ligands were linked to the inhibition of cell