… Although to date clinical studies have not been able to prove the benefits of xanthine
oxidase in HF patients, we discuss the putative role of UA and xanthine oxidase in the …

… Energy production becomes less efficient in failing hearts, … conversion of xanthine
dehydrogenase to xanthine oxidase in … Increased expression and activity of NOX2 has been …

… pathological conditions, such as chronic heart failure (7), obesity (… In this regard, increased
XO expression and oxidative stress … Following an increased hepatic expression XO, it is then …

… in patients with heart failure indicate that xanthine oxidase (XO) activity is involved (6). …
heart failure. Some studies have shown increased expression and activity of MMPs in the hearts …

… the cardiac tissue UA level might increase in the failing heart … that cardiac tissue XDH activity
was significantly increased in … significantly reduced cardiac XDH activity (Supplementary Fig…

… increased expression of XO, IL-33, and CCL2, compared to those not added with uric acid.
Currently, IL-33 is described as a member of the IL-1 family expressed … , chronic heart failure, …

… On the contrary, large long-term clinical trials have demonstrated that xanthine oxidase … in
patients affected by chronic diseases such as heart failure and cancer, and in patients taking a …

… We hypothesized that carotid plaques from symptomatic patients are characterized by an
increased expression of XO, which would be related to cardiovascular risk factors and serum …

… In addition to being the primary cause of gout, elevated xanthine oxidase is also to blame …
Increased levels of uric acid predict haemodynamic compromise in patients with heart failure …

… In the heart, ROS derive from various sources, such as NADPH oxidases, xanthine oxidase,
… While mitochondria are the primary source of ROS in the heart, communication between …