Sodium acetate protects against nicotine-induced excess hepatic lipid in male rats by suppressing xanthine oxidase activity

EO Dangana, TE Omolekulo, ED Areola… - Chemico-Biological …, 2020 - Elsevier
… Particularly, hepatic IR plays a major role and results in the failure of insulin to suppress
hepatic … Blood sample was collected by cardiac puncture into heparinized bottle and was …

Discovery of new therapeutic redox targets for cardioprotection against ischemia/reperfusion injury and heart failure

A Daiber, I Andreadou, M Oelze, SM Davidson… - Free Radical Biology …, 2021 - Elsevier
… to ischemic heart disease and subsequent acute myocardial infarction and heart failure, …
by various sources (NADPH oxidases, xanthine oxidase and mitochondrial resperatory chain) …

Cardioprotective effects of sirtuin-1 and its downstream effectors: potential role in mediating the heart failure benefits of SGLT2 (sodium-glucose cotransporter 2) …

M Packer - Circulation: Heart Failure, 2020 - Am Heart Assoc
activity of xanthine oxidase and that of both SIRT1 and PGC-1α. Stimulation of xanthine
oxidase … to downregulation of xanthine oxidase 80 ; and inhibition of xanthine oxidase leads to …

Comparative studies of xanthine oxidase inhibitors viz. allopurinol and febuxostat against induced hyperuricaemia in a poultry model

S Kumar, MK Gupta, S Kumar, T Rana - Avian Pathology, 2024 - Taylor & Francis
… Both allopurinol and febuxostat inhibits xanthine oxidasebetter expressed by febuxostat
as compared to allopurinol. … risk of death with febuxostat in patient having history of heart

Cardio-renal protective effect of the xanthine oxidase inhibitor febuxostat in the 5/6 nephrectomy model with hyperuricemia

H Omizo, Y Tamura, C Morimoto, M Ueno, Y Hayama… - Scientific reports, 2020 - nature.com
… use in chronic heart failure: association with improved survival. J Card Fail 18, 694–701, …
Structure and function of xanthine oxidoreductase: where are we now? Free Radic Biol Med …

Tissue xanthine oxidoreductase activity in a mouse model of aristolochic acid nephropathy

T Ishii, T Kumagae, H Wakui, S Urate, S Tanaka… - FEBS Open …, 2021 - Wiley Online Library
… damage due to renal failure. In this study, we analyzed XOR activity in the kidneys, plasma,
heart, liver, … We chose AA because it shows the fibrotic mechanism to end-stage renal failure, …

MO631 XANTHINE OXIDASE INHIBITOR AMELIORATES HIGH GLUCOSE-INDUCED OXIDATIVE STRESS BY ACTIVATING AMPK VIA THE ACTIVATION OF …

YA Hong, KJ Yang, WJ Choi, YK Chang… - Nephrology Dialysis …, 2021 - academic.oup.com
… frequent hypotensions, coronary heart disease, and cardiac heart failure are other difficult to
… diabetes like the second cause of arteriovenous fistulas failure, after the age of patients so …

Protective effect of febuxostat in sepsis-induced liver and kidney injuries after cecal ligation and puncture with the impact of xanthine oxidase, interleukin 1β, and c …

YF Ibrahim, RR Fadl, SAE Ibrahim… - Human & …, 2020 - journals.sagepub.com
… dismutase activity and total antioxidant capacity. In addition, CLP caused increased expression
… organ failure in sepsis. In our study, we found that there was an increase in IL-1β protein …

Isorhamnetin, the xanthine oxidase inhibitor from Sophora japonica, ameliorates uric acid levels and renal function in hyperuricemic mice

F Wang, X Zhao, X Su, D Song, F Zou, L Fang - Food & Function, 2021 - pubs.rsc.org
… Hyperuricemia is a metabolic condition closely linked to xanthine oxidase (XOD) function, …
chronic renal failure and acromegaly, residual Cr levels are usually significantly increased due …

Skeletal muscle as a reservoir for nitrate and nitrite: The role of xanthine oxidase reductase (XOR)

JO de Zevallos, MN Woessner, EE Kelley - Nitric Oxide, 2022 - Elsevier
… The latter can also be accompanied with an increased expression of sialin (ie NO 3 −
transporter) to maintain skeletal muscle N-oxides, which combined may help to maintain NO …