EGFR-targeted photodynamic therapy

L Ulfo, PE Costantini, M Di Giosia, A Danielli… - Pharmaceutics, 2022 - mdpi.com
… The epidermal growth factor receptor (EGFR) plays a pivotal … the EGFR inhibitor (Ne) [128].
Interestingly, NBSNe inhibited tumor … A chitosan derivative for targeting EGFR-overexpressing …

MEK or ERK inhibition effectively abrogates emergence of acquired osimertinib resistance in the treatment of epidermal growth factor receptor–mutant lung cancers

J Gu, W Yao, P Shi, G Zhang, TK Owonikoko… - Cancer, 2020 - Wiley Online Library
epidermal growth factor receptor (EGFR) mutations respond well to osimertinib (AZD9291),
a third-generation, mutation-selective EGFR inhibitor. The … patient-derived xenografts would …

Structural insight and development of EGFR tyrosine kinase inhibitors

T Amelia, RE Kartasasmita, T Ohwada, DH Tjahjono - Molecules, 2022 - mdpi.com
therapy such as tyrosine kinase inhibitor for Epidermal Growth Factor Receptor (EGFR), …
(E884K) that may reduce sensitivity to different EGFR inhibitors [72]. Several mutations at the …

Anti-EGFR therapy induces EGF secretion by cancer-associated fibroblasts to confer colorectal cancer chemoresistance

CM Garvey, R Lau, A Sanchez, RX Sun, EJ Fong… - Cancers, 2020 - mdpi.com
therapy targeting the epidermal growth factor receptor (EGFR… collectively encounter EGFR
inhibition during cetuximab treatment. … that cetuximab treatment causes patient-derived CAFs …

Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours

JM Fernandes Neto, E Nadal, E Bosdriesz… - Nature …, 2020 - nature.com
derived xenograft (PDX) tumours from four different patients who had developed resistance
to first-line or second-line therapy with EGFR inhibitors … activated when growth factors are …

[HTML][HTML] Treating disease progression with osimertinib in EGFR-mutated non-small-cell lung cancer: novel targeted agents and combination strategies

V Di Noia, A D'aveni, E D'argento, S Rossi… - ESMO open, 2021 - Elsevier
… mutations of epidermal growth factor receptor (EGFR) are the … may derive more benefit from
a combination treatment with … -generation TKIs can restore EGFR inhibition. To date, clinical …

Use of epidermal growth factor receptor inhibitor erlotinib to treat palmoplantar keratoderma in patients with Olmsted syndrome caused by TRPV3 mutations

C Greco, S Leclerc-Mercier, S Chaumon… - JAMA …, 2020 - jamanetwork.com
EGFR transactivation. We proposed administering erlotinib hydrochloride, an EGFR inhibitor,
to treat 3 … informed consent was obtained from the patients’ parents prior to starting therapy. …

EGFR-Based targeted therapy for colorectal cancer—Promises and challenges

B Janani, M Vijayakumar, K Priya, JH Kim… - Vaccines, 2022 - mdpi.com
… impact of the epidermal growth factor receptor (EGFR) on the … and selective anti-EGFR
inhibitors, particularly monoclonal … contrast of NIRF signals was obtained between HCT-116 …

[HTML][HTML] Dual EGFR-VEGF pathway inhibition: a promising strategy for patients with EGFR-mutant NSCLC

X Le, M Nilsson, J Goldman, M Reck… - Journal of Thoracic …, 2021 - Elsevier
… and EGFR inhibition represent a rational combination strategy for EGFR-mutant NSCLC
treatment. In … Nintedanib inhibits fibroblast growth factor receptor, PDGF receptor, and VEGFR. …

ERK inhibition effectively overcomes acquired resistance of epidermal growth factor receptor‐mutant non–small cell lung cancer cells to osimertinib

Y Li, H Zang, G Qian, TK Owonikoko, SR Ramalingam… - Cancer, 2020 - Wiley Online Library
… drug for the treatment of patients who have NSCLC with activating EGFR mutations (…
epidermal growth factor receptor tyrosine kinase inhibitors. Osimertinib-resistant cell lines derived