Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy
Y Lu, YT Chan, HY Tan, S Li, N Wang, Y Feng - Molecular cancer, 2020 - Springer
… As the epigenetic modifiers are susceptible to extrinsic factors and reversible, they are
becoming promising targets in multiple cancer therapies. Recently, various epi-drugs have been …
becoming promising targets in multiple cancer therapies. Recently, various epi-drugs have been …
Cancer's epigenetic drugs: where are they in the cancer medicines?
S Ghasemi - The pharmacogenomics journal, 2020 - nature.com
… epigenetic genes, they can be considered as potential targets for cancer treatment. In this …
Despite many challenges, combination therapy using epi-drugs and routine therapies such as …
Despite many challenges, combination therapy using epi-drugs and routine therapies such as …
Predictive biomarkers and potential drug combinations of epi-drugs in cancer therapy
T Yang, Y Yang, Y Wang - Clinical Epigenetics, 2021 - Springer
… patients. Here, we review the predictive biomarkers of 12 epi-drugs as well as the progress
of combination therapy … Emerging epigenetic drugs (epi-drugs) target enzymes involved in …
of combination therapy … Emerging epigenetic drugs (epi-drugs) target enzymes involved in …
[HTML][HTML] Targeting epigenetic regulatory enzymes for cancer therapeutics: novel small-molecule epidrug development
Y Jin, T Liu, H Luo, Y Liu, D Liu - Frontiers in Oncology, 2022 - frontiersin.org
… These compounds target epigenetic regulatory enzymes, … that target epigenetic regulatory
enzymes in cancer treatment. Finally… can target epigenetic regulatory enzymes to treat cancer. …
enzymes in cancer treatment. Finally… can target epigenetic regulatory enzymes to treat cancer. …
Epigenetic Regulation in Breast Cancer: Insights on Epidrugs
A Kim, K Mo, H Kwon, S Choe, M Park, W Kwak… - Epigenomes, 2023 - mdpi.com
… are promising for drug development targeting cancer epigenetic genes. In this review, we
discuss the importance of epigenetic regulation and the potential of epidrugs in breast cancer. …
discuss the importance of epigenetic regulation and the potential of epidrugs in breast cancer. …
Epidrugs: novel epigenetic regulators that open a new window for targeting osteoblast differentiation
M Ghorbaninejad, M Khademi-Shirvan… - … Research & Therapy, 2020 - Springer
… A number of studies mentioned the role of epigenetic inhibitors in the regulation of … ,
epigenetic mechanisms. In addition, we propose to introduce epigenetic enzyme inhibitors (epidrugs…
epigenetic mechanisms. In addition, we propose to introduce epigenetic enzyme inhibitors (epidrugs…
[HTML][HTML] Epidrug repurposing: discovering new faces of old acquaintances in cancer therapy
M Montalvo-Casimiro, R González-Barrios… - … in oncology, 2020 - frontiersin.org
… approved epidrugs, and their druggable targets, that are currently being used in cancer
therapy. … epigenetic therapy in cancer, contributing to the development of precision medicine in …
therapy. … epigenetic therapy in cancer, contributing to the development of precision medicine in …
Combining epigenetic drugs with other therapies for solid tumours—past lessons and future promise
D Morel, D Jeffery, S Aspeslagh, G Almouzni… - … Clinical Oncology, 2020 - nature.com
… epi-drugs can modulate the sensitivity of cancer cells to other forms of anticancer therapy,
including chemotherapy, radiation therapy… Current epigenetic drugs (epi-drugs) target proteins …
including chemotherapy, radiation therapy… Current epigenetic drugs (epi-drugs) target proteins …
[HTML][HTML] Towards a more precise therapy in cancer: Exploring epigenetic complexity
FP Cossío, M Esteller, M Berdasco - Current Opinion in Chemical Biology, 2020 - Elsevier
… use of epidrugs in the treatment of human cancer, including the lack of specificity of epidrugs,
… opportunities for targeting epigenetic alterations to make further advances in precision …
… opportunities for targeting epigenetic alterations to make further advances in precision …
Epigenetic alterations as therapeutic targets in Testicular Germ Cell Tumours: Current and future application of 'epidrugs'
AR Cardoso, J Lobo, V Miranda-Gonçalves… - Epigenetics, 2021 - Taylor & Francis
… potential targets to design epigenetic … epigenetic mechanisms at play in these neoplasms,
the current challenges in the field of TGCTs and critically reviews available data on ‘epidrugs…
the current challenges in the field of TGCTs and critically reviews available data on ‘epidrugs…