Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy

Y Lu, YT Chan, HY Tan, S Li, N Wang, Y Feng - Molecular cancer, 2020 - Springer
… As the epigenetic modifiers are susceptible to extrinsic factors and reversible, they are
becoming promising targets in multiple cancer therapies. Recently, various epi-drugs have been …

Cancer's epigenetic drugs: where are they in the cancer medicines?

S Ghasemi - The pharmacogenomics journal, 2020 - nature.com
epigenetic genes, they can be considered as potential targets for cancer treatment. In this …
Despite many challenges, combination therapy using epi-drugs and routine therapies such as …

Predictive biomarkers and potential drug combinations of epi-drugs in cancer therapy

T Yang, Y Yang, Y Wang - Clinical Epigenetics, 2021 - Springer
patients. Here, we review the predictive biomarkers of 12 epi-drugs as well as the progress
of combination therapy … Emerging epigenetic drugs (epi-drugs) target enzymes involved in …

[HTML][HTML] Targeting epigenetic regulatory enzymes for cancer therapeutics: novel small-molecule epidrug development

Y Jin, T Liu, H Luo, Y Liu, D Liu - Frontiers in Oncology, 2022 - frontiersin.org
… These compounds target epigenetic regulatory enzymes, … that target epigenetic regulatory
enzymes in cancer treatment. Finally… can target epigenetic regulatory enzymes to treat cancer. …

Epigenetic Regulation in Breast Cancer: Insights on Epidrugs

A Kim, K Mo, H Kwon, S Choe, M Park, W Kwak… - Epigenomes, 2023 - mdpi.com
… are promising for drug development targeting cancer epigenetic genes. In this review, we
discuss the importance of epigenetic regulation and the potential of epidrugs in breast cancer. …

Epidrugs: novel epigenetic regulators that open a new window for targeting osteoblast differentiation

M Ghorbaninejad, M Khademi-Shirvan… - … Research & Therapy, 2020 - Springer
… A number of studies mentioned the role of epigenetic inhibitors in the regulation of … ,
epigenetic mechanisms. In addition, we propose to introduce epigenetic enzyme inhibitors (epidrugs

[HTML][HTML] Epidrug repurposing: discovering new faces of old acquaintances in cancer therapy

M Montalvo-Casimiro, R González-Barrios… - … in oncology, 2020 - frontiersin.org
… approved epidrugs, and their druggable targets, that are currently being used in cancer
therapy. … epigenetic therapy in cancer, contributing to the development of precision medicine in …

Combining epigenetic drugs with other therapies for solid tumours—past lessons and future promise

D Morel, D Jeffery, S Aspeslagh, G Almouzni… - … Clinical Oncology, 2020 - nature.com
epi-drugs can modulate the sensitivity of cancer cells to other forms of anticancer therapy,
including chemotherapy, radiation therapy… Current epigenetic drugs (epi-drugs) target proteins …

[HTML][HTML] Towards a more precise therapy in cancer: Exploring epigenetic complexity

FP Cossío, M Esteller, M Berdasco - Current Opinion in Chemical Biology, 2020 - Elsevier
… use of epidrugs in the treatment of human cancer, including the lack of specificity of epidrugs,
… opportunities for targeting epigenetic alterations to make further advances in precision …

Epigenetic alterations as therapeutic targets in Testicular Germ Cell Tumours: Current and future application of 'epidrugs'

AR Cardoso, J Lobo, V Miranda-Gonçalves… - Epigenetics, 2021 - Taylor & Francis
… potential targets to design epigeneticepigenetic mechanisms at play in these neoplasms,
the current challenges in the field of TGCTs and critically reviews available data on ‘epidrugs