… different phenotypes so that epigenetic marks can persist during … of epigenetic marks includes
DNA methylation, histone modification, … Unlike genetic mutations, epigenetic modulation in …

… In addition to the study of germline genetic changes, epigenetic changes affecting the modulation
of … AntimiRNAs are small molecules that bind to the target miRNA and inhibit its activity, …

… study of genome-wide changes in epigenetic mechanisms, including DNA methylation and
… Epigenetics begins with DNA and histone proteins by two mechanisms: methylation of the C5 …

… DNA repair, cell proliferation, and mortality (3, 4). Therefore, epigenetic marks such as DNA
methylation, histone … In recent years, many small-molecule compounds targeting epigenetic …

… key aberrant epigenetic processes — DNA methylation and … as the effects of epigenetic
modulation on antitumour immune … JMJD3/UTX using the small molecule GSK-J4 led to …

… ), catalyze the transfer of epigenetic marks into either DNA or histones. … DNA Methyltransferase
with Covalent Small-Molecule Inhibitors DNA methylation is a mammalian epigenetic …

… Both DNA methylation and the modulation of chromatin structure have major effects on the
… acetylation and DNA methylation. Small molecule histone deacetylase (HDAC) and DNA …

… DNA methylation is a major epigenetic modification that plays a significant role in gene … in
DNA methylation or histone modifications, it is possible to alter the epigenetic landscape and …

… Various mutations in BRPF1 have been implicated in acute leukemias, and therapeutic
targeting of BRPF1 by small molecules is emerging as an attractive strategy for AML therapy [66]. …

… HDAC inhibitors are well-studied small molecules … epigenetic changes such as enhancement
of histone acetylation levels (ie H3ac and H4ac) and decrease of methylation of histones (…