[HTML][HTML] New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities

M Ashrafizadeh, S Mirzaei, F Hashemi, A Zarrabi… - Biomedicine & …, 2021 - Elsevier
Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for metastasis and …
in mediating drug resistance of cancer cells. On the other hand, paclitaxel (PTX) and docetaxel

Epithelial–mesenchymal transition programs and cancer stem cell phenotypes: mediators of breast cancer therapy resistance

AJ Gooding, WP Schiemann - Molecular Cancer Research, 2020 - AACR
… assessing the 10-year risk of distant recurrence in stage I or II … role in mediating both de
novo and acquired resistance to … Along these lines, TNBC resistance to docetaxel reflects the …

[HTML][HTML] Overview of evidence-based chemotherapy for oral cancer: focus on drug resistance related to the epithelial-mesenchymal transition

J Sha, Y Bai, HX Ngo, T Okui, T Kanno - Biomolecules, 2021 - mdpi.com
… This transition from epithelial to mesenchymal cells is … of inhibiting EMT-mediated
resistance to chemotherapy agents. … with the development of resistance or recurrence, multiple …

Docetaxel Inhibits Epithelial–Mesenchymal Transition in Human Mammary Cells

SJ Beerkens, JJ King, KL Irving, S Bhatia… - Molecular …, 2023 - ACS Publications
… increase the chance of tumor recurrence and resistance, calling … , there remains an elevated
risk of tumor recurrence and death … in relation to docetaxel-mediated inhibition of EMT. …

[HTML][HTML] Cell plasticity and prostate cancer: The role of epithelial–mesenchymal transition in tumor progression, invasion, metastasis and cancer therapy resistance

S Papanikolaou, A Vourda, S Syggelos, K Gyftopoulos - Cancers, 2021 - mdpi.com
… ) acts as an epithelial-to-mesenchymal transition (EMT)-… Ezh2 could overcome docetaxel
resistance in PCa cells, by … for treatment failure and CSC-mediated clinical relapse [236]. In …

[HTML][HTML] Association of the epithelial–mesenchymal transition (EMT) with cisplatin resistance

M Ashrafizadeh, A Zarrabi, K Hushmandi… - International journal of …, 2020 - mdpi.com
… the inhibition of EMT-mediated resistance displayed by tumor … It is worth mentioning that
CP and docetaxel (DOX) can be … as a vital reason for the recurrence of cancer. Prior studies …

[HTML][HTML] Epithelial–mesenchymal transition-mediated tumor therapeutic resistance

Z Xu, Y Zhang, H Dai, B Han - Molecules, 2022 - mdpi.com
… a high mortality rate threat. Tumor recurrence and metastasis due to treatment resistance are
… The epithelial–mesenchymal transition (EMT) is essential for tumor drug resistance. EMT …

[HTML][HTML] CNTN-1 promotes docetaxel resistance and epithelial-to-mesenchymal transition via the PI3K/Akt signaling pathway in prostate cancer

B Chen, Y Zhang, C Li, P Xu, Y Gao… - Archives of Medical …, 2021 - ncbi.nlm.nih.gov
… the PI3K activator IGF-1 at the same time. These data … to mediate EMT and Dox resistance.
Similarly, in vivo experiments showed that CNTN-1 silencing significantly increased docetaxel-…

[HTML][HTML] Overcoming therapeutic resistance to platinum-based drugs by targeting Epithelial–Mesenchymal transition

X Duan, M Luo, J Li, Z Shen, K Xie - Frontiers in oncology, 2022 - frontiersin.org
… of these genes was mediated by EMT program activation (89). … resistance than completed
EMT cells, we selected docetaxel-… on tumor recurrence, metastasis, and drug resistance, which …

[HTML][HTML] Chemotherapeutic stress influences epithelial–mesenchymal transition and stemness in cancer stem cells of triple-negative breast cancer

X Li, J Strietz, A Bleilevens, E Stickeler… - International journal of …, 2020 - mdpi.com
… indicating a high risk for distant tumor recurrence within the … breast cancer while inducing
docetaxel resistance in prostate … an important role in mediating cisplatin resistance in ovarian …