Neuregulins 1, 2, and 3 promote early neurite outgrowth in ErbB4-expressing cortical GABAergic interneurons

A Rahman-Enyart, C Lai, AL Prieto - Molecular Neurobiology, 2020 - Springer
… of signaling molecules that play diverse roles in the nervous system. Nrg1 has been implicated
in the formation of synapses and in synaptic … persisted throughout the dendritic arbor and …

Neuregulin 1: an intriguing therapeutic target for neurodevelopmental disorders

L Shi, CM Bergson - Translational Psychiatry, 2020 - nature.com
… ) across critical period development in mouse visual cortex 51 . The synaptic remodeling
during critical period development … and noise filtering during arousal by modulating the basal …

Dysregulation of ErbB4 Signaling Pathway in the Dorsal Hippocampus after Neonatal Hypoxia-Ischemia and Late Deficits in PV+ Interneurons, Synaptic Plasticity and …

H Spahic, P Parmar, S Miller, PC Emerson… - International journal of …, 2022 - mdpi.com
… downstream effects to support PV + IN dendritic arborization [28,29]. Genetic … dendrites
of pyramidal cells modulating their synaptic activity. Puncta expressing Syt2, a pre-synaptic

[HTML][HTML] Neuregulins: subcellular localization, signaling pathways and their relationship with neuroplasticity and neurological diseases

M Longart, C Calderón, M González… - Exploration of …, 2022 - explorationpub.com
… the main signaling pathways by which these proteins act, NRG function in neurite development
and synapse formation, the modulation of … NRG1 also increases dendritic arborization of …

The ketogenic diet increases Neuregulin 1 expression via elevating histone acetylation and its anti-seizure effect requires ErbB4 kinase activity

J Wang, J Huang, S Yao, JH Wu, HB Li, F Gao… - Cell & Bioscience, 2021 - Springer
… HDAC is involved in the modulation of KD on acetylation and … /ErbB4 signaling decreases
GABAergic synaptic activity and thus … NRG1/ErbB4 signaling regulates GABA synaptic activity. …

Dysfunction of NRG1/ErbB4 signaling in the Hippocampus might mediate long-term memory decline after systemic inflammation

Y Gao, X Wu, Z Zhou, P Liu, J Yang, M Ji - Molecular Neurobiology, 2023 - Springer
… These results demonstrate that ErbB4 is critical for NRG1 effects on modulation of synaptic
… Importantly, recent work indicates that NRG1/ErbB4 signaling also modulates local field …

… -and depressive-like behavior of male offspring rats through intrauterine programming of the activation of NRG1-ErbB4 signaling in hippocampal PV interneurons

S Zhang, S Hu, W Dong, S Huang, Z Jiao, Z Hu… - Cell Biology and …, 2023 - Springer
… NRG1-ErbB4 signaling in the rat hippocampus, causes synaptic microcircuitry imbalance …
damage PV interneurons through the programmed activation of NRG1-ErbB4 signaling, we …

Developmental Disruption of Erbb4 in Pet1+ Neurons Impairs Serotonergic Sub-System Connectivity and Memory Formation

C Barettino, Á Ballesteros-Gonzalez, A Aylón… - Frontiers in Cell and …, 2021 - frontiersin.org
… combination of guidance and signaling molecules as well as environmental factors during
development, our findings reinforce the notion that intrinsic signaling pathways regulated by …

Extreme glycemic fluctuations debilitate NRG1, ErbB receptors and Olig1 function: association with regeneration, cognition and mood alterations during diabetes

M Joshi, DP Shah, A Krishnakumar - Molecular Neurobiology, 2021 - Springer
… The NRG1-ErbB receptor signaling is a key pathway for regeneration in adult brain and
also associated with learning and mood stabilization by modulating synaptic transmission. …

[HTML][HTML] NRG1-ErbB4 signaling in the medial amygdala controls mating motivation in adult male mice

J Huang, YY Zhang, YY Qiu, S Yao, WT Qiu, JL Peng… - Cell Reports, 2024 - cell.com
… of ErbB4-positive neuronal activities bidirectionally modulate mating motivation. We also
identify that the effects of NRG1-ErbB4 signaling on neuronal excitability and mating motivation …