PLAGL2‐EGFR‐HIF‐1/2α signaling loop promotes HCC progression and erlotinib insensitivity
W Hu, S Zheng, H Guo, B Dai, J Ni, Y Shi, H Bian… - …, 2021 - Wiley Online Library
… common type of liver cancer worldwide. It is estimated to be … can also induce cell cycle
regulation and apoptosis through … cells and neuroblastoma Neuroa2a cells led to an increase in …
regulation and apoptosis through … cells and neuroblastoma Neuroa2a cells led to an increase in …
Titanium oxide nanoparticles improve the chemotherapeutic action of erlotinib in liver cancer cells
SE Abdel-Ghany, E El-Sayed, N Ashraf… - Current Cancer …, 2020 - ingentaconnect.com
… proved to be a reliable approach to enhance drug release and bioavailability. Our results …
lotinib induces cell cycle arrest and apoptosis in hepatocellular cancer cells and enhances …
lotinib induces cell cycle arrest and apoptosis in hepatocellular cancer cells and enhances …
2-Methoxyestradiol synergizes with Erlotinib to suppress hepatocellular carcinoma by disrupting the PLAGL2-EGFR-HIF-1/2α signaling loop
S Zheng, J Ni, Y Li, M Lu, Y Yao, H Guo, M Jiao… - Pharmacological …, 2021 - Elsevier
… into cancer chemotherapy. However, the therapeutic effects of erlotinib in hepatocellular
carcinoma (… 2ME2 promotes tumor cells apoptosis and inhibits tumor cells proliferative in several …
carcinoma (… 2ME2 promotes tumor cells apoptosis and inhibits tumor cells proliferative in several …
[HTML][HTML] β-elemene enhances the antitumor activity of erlotinib by inducing apoptosis through AMPK and MAPK pathways in TKI-resistant H1975 lung cancer cells
… Cell cycle arrest can save time for DNA repair. On the other hand, if the intracellular damage
… of tumors including lung cancer, liver cancer, digestive tract cancer, and bladder cancer, etc.…
… of tumors including lung cancer, liver cancer, digestive tract cancer, and bladder cancer, etc.…
Elafin promotes tumour metastasis and attenuates the anti-metastatic effects of erlotinib via binding to EGFR in hepatocellular carcinoma
… early-stage hepatocellular carcinoma (HCC) … erlotinib could partly inhibit Elafin induced
HCC metastasis and EGFR/AKT signalling activation, and the combination of erlotinib treatment …
HCC metastasis and EGFR/AKT signalling activation, and the combination of erlotinib treatment …
Inactivation of EGFR/ERK/NF‐κB signalling associates with radiosensitizing effect of 18β‐glycyrrhetinic acid on progression of hepatocellular carcinoma
YC Liu, CH Lin, KT Chen, DW Lai… - Journal of Cellular and …, 2023 - Wiley Online Library
… of DNA repair mechanism, induction of apoptosis and cell cycle arrest. In addition, antitumor
… that erlotinib as a radiosensitizer significantly enhanced radiation-inhibited tumour growth in …
… that erlotinib as a radiosensitizer significantly enhanced radiation-inhibited tumour growth in …
Novel Ferrocene Derivatives Induce G0/G1 Cell Cycle Arrest and Apoptosis through the Mitochondrial Pathway in Human Hepatocellular Carcinoma
J Zheng, L Zeng, M Tang, H Lin, C Pi, R Xu… - International Journal of …, 2021 - mdpi.com
… Furthermore, the antiproliferative effect of compound 1 was associated with G0/G1 phase
cell cycle arrest and the intrinsic apoptotic pathway, ie, decrease in Bcl-2 protein, increase in …
cell cycle arrest and the intrinsic apoptotic pathway, ie, decrease in Bcl-2 protein, increase in …
Novel EGFR‐MAPK kinase and ABC transporter inhibitors for HepG2 resistant to Erlotinib
… Hepatocellular carcinoma (HCC) is the sixth most common … of the cell cycle arrest in cancer
cells and induction of drug … Around 240ns we see a large increase in the RMSD of MMA102, …
cells and induction of drug … Around 240ns we see a large increase in the RMSD of MMA102, …
A network pharmacology approach to investigate the anticancer mechanism of cinobufagin against hepatocellular carcinoma via downregulation of EGFR-CDK2 …
A Yang, Q Wu, Z Hu, S Wang, Y Tao, A Wang… - Toxicology and applied …, 2021 - Elsevier
… the growth of tumor cells but also enhance the inhibitory effects … These include drugs such
as lapatinib and erlotinib which have … causes cell growth inhibition by inducing G2/M cell cycle …
as lapatinib and erlotinib which have … causes cell growth inhibition by inducing G2/M cell cycle …
Oral squamous cell carcinoma cells with acquired resistance to erlotinib are sensitive to anti-cancer effect of quercetin via pyruvate kinase M2 (PKM2)
CY Chan, SC Hong, CM Chang, YH Chen, PC Liao… - Cells, 2023 - mdpi.com
… of erlotinib-mediated resistance by enhancing apoptosis. In … flow cytometry analysis of the
cell cycle progression. The result … and SMMC-7721 hepatocellular carcinoma (HCC) cells [30]. …
cell cycle progression. The result … and SMMC-7721 hepatocellular carcinoma (HCC) cells [30]. …