New insights into the role of insulin and hypothalamic-pituitary-adrenal (HPA) axis in the metabolic syndrome

JA Janssen - International journal of molecular sciences, 2022 - mdpi.com
… of the sympathetic nervous system to brown adipose tissue and this … Skeletal muscles
play an important role in glucose … prereceptor level by dynamically regulating 11β-HSD1 [106,107]. …

[HTML][HTML] Knockdown of 11β-hydroxysteroid dehydrogenase type 1 alleviates LPS-induced myocardial dysfunction through the AMPK/SIRT1/PGC-1α pathway

D Zhu, L Luo, H Zeng, Z Zhang, M Huang… - Journal of Biomedical …, 2023 - ncbi.nlm.nih.gov
… Considering the role of 11β-HSD1 in inflammation and heart … Moreover, 11β-HSD1 regulates
inflammatory responses, and … Thus, 11β-HSD1 is an essential factor for regulating the …

Novel targets for potential therapeutic use in Diabetes mellitus

S Dhankhar, S Chauhan, DK Mehta, Nitika… - Diabetology & Metabolic …, 2023 - Springer
… the 11β-HSD1 may work in reducing insulin resistance and thus increasing insulin sensitivity
by regulating the … In white adipose tissue (WAT) and Brown adipose tissue (BAT), it reduces …

The stress axis in obesity and diabetes mellitus: an update

L Gianotti, S Belcastro, S D'Agnano, F Tassone - Endocrines, 2021 - mdpi.com
… the decrease of 11β-HSD1 adipose tissue in humans [41,42]. … Catecholamines also carry
out a well known role in the regulation … in primary human brown adipocyte cultures, and acute …

Glucocorticoids increase adiposity by stimulating Krüppel-like factor 9 expression in macrophages

Y Zhang, C Du, W Wang, W Qiao, Y Li, Y Zhang… - Nature …, 2024 - nature.com
… Two enzymes (11β-HSD1 and 11β-HSD2) are responsible … and endocrine signaling,
while brown adipose tissue (BAT) is … by which GCs regulate macrophage function, we next …

[PDF][PDF] Studzi nska

D Kupczyk - Clin. Med, 2022 - academia.edu
… This paper discusses the role of 11β-HSD1 in MetS and its … The basic role of 11β-HSD1 is
to increase the concentration of … The role of 11β-HSD1 includes both “endocrine” regulation of …

The regulatory role of adipocyte mitochondrial homeostasis in metabolism-related diseases

H Song, X Zhang, J Wang, Y Wu, T Xiong… - Frontiers in …, 2023 - frontiersin.org
… a crucial role in maintaining the morphology and function of … in both white adipose tissue
(WAT) and brown adipose tissue (BAT) … hydratase in white and brown adipose tissue resulted in …

Effect of glucocorticoid and 11β-hydroxysteroid-dehydrogenase type 1 (11β-HSD1) in neurological and psychiatric disorders

S Dodd, DR Skvarc, OM Dean… - International Journal …, 2022 - academic.oup.com
… by 11β-HSD1 to active cortisol, which, in turn, regulates the … Type 2 diabetes Phase I ex
vivo analysis of human adipose … , such as UE2343, fundamental questions remain regarding …

Sexual dimorphism in adipose-hypothalamic crosstalk and the contribution of aryl hydrocarbon receptor to regulate energy homeostasis

N Haque, SA Tischkau - International journal of molecular sciences, 2022 - mdpi.com
… is crucial. Overall, this review summarizes sex differences in the … environmental change
occurs in brown adipose tissue (BAT), … Moreover, elevated 11β-HSD1 in BAT increases the …

The mineralocorticoid receptor—an emerging player in metabolic syndrome?

M Thuzar, M Stowasser - Journal of Human Hypertension, 2021 - nature.com
… (MR) plays an important role in blood pressure regulation via its effect on salt … Adipose
tissues do not display significant levels of 11βHSD2 while expressing high levels of 11β-HSD1