Activation of estrogen receptor α inhibits TLR4 signaling in macrophages and alleviates the instability of atherosclerotic plaques in the postmenopausal stage

Q Meng, Y Bi, H Feng, X Ding, S Zhang, Q Chen… - International …, 2023 - Elsevier
… for acute cardiovascular events [1]. The risk of cardiovascular disease is greatly increased
when menopause occurs in women, and the mortality rate of ischemic heart disease is higher …

[HTML][HTML] Association of endometriosis with cardiovascular disease: Genetic aspects

VM Vazgiourakis, MI Zervou… - International …, 2023 - spandidos-publications.com
… , with endothelial cells (ECs), smooth muscle cells (SMCs) … and rs13394619 in growth
regulating estrogen receptor binding 1 … in programmed cell death (apoptosis), cell cycle regulation, …

Network pharmacology and in vitro studies show the pharmacological effects and molecular mechanisms of salidroside against coronary artery disease

B Jiang, X Feng, Z Wang, J Xu, T Yang, L Feng, X Zhou… - 2022 - researchsquare.com
… , apoptosis, diabetic cardiomyopathy and estrogen signaling … in vascular epithelial cells
and can interfere the growth, … -infarction cardiac dysfunction by up-regulating autophagy …

Pharmacological effects of genistein on cardiovascular diseases

S Jafari, M Shoghi, MR Khazdair - … ‐Based Complementary and …, 2023 - Wiley Online Library
… natural estrogen and, finally, inhibition of cancer cell growth … through inhibiting caspase-3
expression and up-regulating … nM) administration in human umbilical vein endothelial cells (…

[HTML][HTML] Estrogen receptor function: impact on the human endometrium

K Yu, ZY Huang, XL Xu, J Li, XW Fu… - Frontiers in …, 2022 - frontiersin.org
… stimulated epithelial cell growth, but apoptosis in the epithelial cells significantly increased
… These studies might help to determine how the proliferation of uterine epithelial is mediated …

[HTML][HTML] Risk Factors and Cellular Differences in Heart Failure: The Key Role of Sex Hormones

E Delcuratolo, A Palazzuoli, F Coppi, AV Mattioli… - Biomedicines, 2023 - mdpi.com
… and heart valve disease, while coronary artery disease is … reduction in the level of
estrogen leads to a further reduction … and migration of the precursors of endothelial cells [102,103]. …

MicroRNA-520c-3p suppresses vascular endothelium dysfunction by targeting RELA and regulating the AKT and NF-κB signaling pathways

Y Jiao, D Zhao, F Gao, X Hu, X Hu, M Li, Y Cui… - Journal of physiology …, 2021 - Springer
… migration of vascular smooth muscle cells by up-regulating miR-… increased in MLCK knockout
rat smooth muscle cells (data … inflammation and apoptosis of vascular endothelial cells, we …

[HTML][HTML] Natural products modulate cell apoptosis: a promising way for treating endometrial cancer

X Zhou, Y Zeng, R Zheng, Y Wang, T Li… - Frontiers in …, 2023 - frontiersin.org
… by programmed cell growth and death. The long-term effects of estrogen without progestin
… inhibition in vitro and in vivo via up-regulating caspase-3, caspase −7 and PARP (Wu C.-H. …

MiR-32-3p regulates myocardial injury induced by microembolism and microvascular obstruction by targeting RNF13 to regulate the stability of atherosclerotic plaques

D Huang, Y Liu, L Gao, X Wei, Y Xu, R Cai… - Journal of cardiovascular …, 2022 - Springer
… pathological lesions in arterial tissue, up-regulating ER stress… plaque and a coronary
artery microembolization (CME) … on vascular endothelial cells and eventually lead to vascular

DHEA promotes ovarian angiogenesis and improves ovarian function in POI rats by up-regulating HIF-1α/VEGF signalling

Y Zhao, J Wang, W Qin, Q Hu, J Li, R Qin, N Ma… - Reproductive …, 2024 - Elsevier
cell apoptosis, D28 ovarian granulosa cell apoptosis was … of endothelial cells are key steps
in angiogenesis and vascular … This study investigated the effects of DHEA on endothelial cell