Investigating the factors associated with the level of expression of estrogen and progesterone receptors in patients suffering from colorectal cancer

S Salehi far, M Soltani, M Zardast… - Journal of Cancer …, 2021 - Wiley Online Library
… level of expression of estrogen plus progesterone receptors and grade of cancer (P = 0.001)…
colorectal cancer showed lower level of expression of estrogen and progesterone receptors. …

[HTML][HTML] Estrogen and progesterone expression in colorectal carcinoma: A clinicopathological study

AAEG Abd ElLateef, AES Mohamed… - … Journal of Cancer …, 2020 - ncbi.nlm.nih.gov
Sex steroids have been suggested to influence colorectal cancer (CRC) carcinogenesis. Also,
exposure to exogenous hormones might contribute to its incidence. This study conducted …

[HTML][HTML] Profiling estrogen, progesterone, and androgen receptors in colorectal cancer in relation to gender, menopausal status, clinical stage, and tumour sidedness

B Refaat, A Aslam, S Idris, AH Almalki… - Frontiers in …, 2023 - frontiersin.org
Background Although estrogen (ERα/ERβ), progesterone (PGR), and androgen (AR)
receptors are pathologically altered in colorectal cancer (CRC), their simultaneous expression …

[HTML][HTML] Therapeutic strategies and potential actions of female sex steroid hormones and their receptors in Colon cancer based on preclinical studies

AA Mahbub - Life, 2022 - mdpi.com
… sex steroid hormones could reduce the risk of colon cancer (… available data related to estradiol
(E2) and progesterone (P4) … receptor, endogenous expression of progesterone receptor, …

[HTML][HTML] Estrogen receptors in colorectal cancer: Facts, novelties and perspectives

I Ditonno, G Losurdo, M Rendina, M Pricci, B Girardi… - Current …, 2021 - mdpi.com
colon cancer cells with ERβ gene constructed into adenoviral vectors alone or in combination
with raloxifene, a selective estrogen receptor … agent in HCT116 colon cancer cells by …

Systemic distribution of progesterone receptor subtypes in human tissues

T Asavasupreechar, R Saito, Y Miki… - The Journal of steroid …, 2020 - Elsevier
estrogen and progesterone sex steroids and their receptors … low levels in the crypt of the
small intestine and colon. The … cancer, colorectal cancer, testis cancer, lung cancer, stomach …

[HTML][HTML] New insights into the functions of progesterone receptor (PR) isoforms and progesterone signaling

JM Azeez, TR Susmi, V Remadevi… - … journal of cancer …, 2021 - ncbi.nlm.nih.gov
… cells induces apoptosis through activation of estrogen receptor β [128]. Folic acid inhibits
colorectal cancer cell growth and migration through progesterone receptor activation [129]. …

[HTML][HTML] Combined estrogen alpha and beta receptor expression has a prognostic significance for colorectal cancer patients

G Topi, S Ghatak, SR Satapathy, R Ehrnström… - Frontiers in …, 2022 - frontiersin.org
… that high estrogen receptor beta (ERβ) expression is independently associated with better
prognosis in female colorectal cancer (CRC) patients. However, estrogen receptor alpha (ERα…

[HTML][HTML] 17β-estradiol in colorectal cancer: friend or foe?

Z Wu, C Xiao, J Wang, M Zhou, F You, X Li - Cell Communication and …, 2024 - Springer
intestinal epithelial cells possess the capability to metabolize estrogen, and fluctuations in E2
levels … Furthermore, we review the impact of E2 on the colorectal tumor microenvironment (…

[HTML][HTML] Involvement of the estrogen and progesterone axis in cancer stemness: elucidating molecular mechanisms and clinical significance

B Chen, P Ye, Y Chen, T Liu, JH Cha, X Yan… - Frontiers in …, 2020 - frontiersin.org
… system and breasts, through estrogen and progesterone receptors, respectively. These
receptors are also important … In patients with colorectal cancer, Lgr5 is an important biomarker of …