17β-estradiol in colorectal cancer: friend or foe?

Z Wu, C Xiao, J Wang, M Zhou, F You, X Li - Cell Communication and …, 2024 - Springer
… breast cancer cells, ERβ suppresses aroundlevels in CRC compared to normal tissues
[16, 26]. Conversely, ERα is expressed at much lower levels than ERβ in normal colonic mucosal

Activation of G protein coupled estrogen receptor prevents chemotherapy-induced intestinal mucositis by inhibiting the DNA damage in crypt cell in an extracellular …

G Chen, H Zeng, X Li, J Liu, Z Li, R Xu, Y Ma… - Cell death & …, 2021 - nature.com
… reduced the intestinal histological damage, weight loss, and mucosal barrier dysfunction, …
Tight junction proteins connecting adjacent IECs and mucosal components secreted by …

Role of gonadally synthesized steroid hormones in the colorectal cancer microenvironment

L Wenxuan, L Liu, L Zhang, Z Qiu, Z Wu… - Frontiers in …, 2023 - frontiersin.org
… to the lives and health of people around the world, and is a … protein levels on both healthy
and cancerous colon mucosa (… and progesterone receptor antagonists inhibit colorectal cancer

Therapeutic strategies and potential actions of female sex steroid hormones and their receptors in Colon cancer based on preclinical studies

AA Mahbub - Life, 2022 - mdpi.com
… , progesterone receptor, endogenous expression of estrogen receptor, endogenous expression
of progesterone receptor, … with their corresponding adjacent normal colon tissues. Others …

[PDF][PDF] Estrogen receptors and inflammation in colorectal cancer. Role in prognosis and therapeutic opportunities.

G Topi - 2020 - portal.research.lu.se
Around eight hundred thousand people are diagnosed with CRC each year. Regarding the
… of this enzyme are expressed to high extend in the normal colon mucosa, but its expression …

Somatostatin and its receptor system in colorectal cancer

A Kasprzak - Biomedicines, 2021 - mdpi.com
… status of estrogen and progesterone receptors was observed [… SST5 in normal colon and
colorectal cancer tissue samples … with adjacent normal mucosa (unpublished data) (Figure 2). …

Delineating the role of nuclear receptors in colorectal cancer, a focused review

MK Manickasamy, S Jayaprakash, S Girisa, A Kumar… - Discover Oncology, 2024 - Springer
Colorectal cancer (CRC) stands as one of the most prevalent form of cancer globally,
causing a significant number of deaths, surpassing 0.9 million in the year 2020. According to …

Estrogen receptor function: impact on the human endometrium

K Yu, ZY Huang, XL Xu, J Li, XW Fu… - Frontiers in …, 2022 - frontiersin.org
estrogen receptors (ERs) to induce mucosal proliferation during the proliferative phase and
progesterone receptor … subpopulation of ERs located in or adjacent to the plasma membrane; …

Protumor role of estrogen receptor expression in oral squamous cell carcinoma cells

R Akyu, K Tomihara, M Yamazaki… - Oral Surgery, Oral …, 2021 - Elsevier
… gingiva, floor of mouth, and buccal mucosa revealed that ERβ was detected in the cytoplasm
… In some normal epithelia adjacent to the carcinoma, positive staining for ERβ was localized …

Investigating the protective role of the novel oestrogen receptor GPER in colorectal cancer

M Abancéns - 2022 - repository.rcsi.com
Progesterone has also been considered as a potential contributor to CRC protection. In
general, normal serum progesterone levels … of oestrogen receptors in the intestinal mucosa of …