Comparison of ischemic preconditioning and systemic piracetam for prevention of ischemia-reperfusion injury in musculocutaneous flaps

A Demiröz, H Derebaşınlıoğlu, A Ercan… - Journal of …, 2021 - thieme-connect.com
… protein, ethyl pyruvate, … on flap survival and VEGF levels after IR injury on skin flaps.[15]
They concluded piracetam does not increase the blood flow of the flap but improves flap survival, …

Pharmacological and cell-based treatments to increase local skin flap viability in animal models

CE Berry, T Le, N An, M Griffin, M Januszyk… - Journal of Translational …, 2024 - Springer
… the glutamate pathway, ultimately resulting in enhanced skin flap survival [67]. The application
of colchicine to ischemia/reperfusion injured rats reduced proinflammatory cytokines IL-6 …

Pyruvate as a potential beneficial anion in resuscitation fluids

FQ Zhou - Frontiers in Medicine, 2022 - frontiersin.org
… a great potential to improve patient survival. Pyruvate-enriched fluids including crystalloids
… is inaccurately referred in many references of ethyl pyruvate (EP) studies (105). Accordingly, …

Systematic review of pathologic markers in skin ischemia with and without reperfusion injury in microsurgical reconstruction: Biomarker alterations precede …

R Khalaf, D Duarte Bateman, J Reyes, D Najafali… - …, 2024 - Wiley Online Library
skin histology or gene/protein expression changes following ischemia with or without
reperfusion injury … flow and subsequent reperfusion injury in animal flap models (IRI) (Table 1). …

Advantages of pyruvate-based fluids in preclinical shock resuscitation-A narrative review

FQ Zhou - Frontiers in Physiology, 2022 - frontiersin.org
… insults, such as ischemiareperfusion injury and/or hemorrhagic, traumatic, … efficient as
Ringer’s ethyl pyruvate solution (REPS) in … Pyruvate alleviation of myocardial injury and improved

Myocardial ischemia-reperfusion injury; Molecular mechanisms and prevention

Y Liu, L Li, Z Wang, J Zhang, Z Zhou - Microvascular Research, 2023 - Elsevier
… Mitophagy is critical process in myocyte survival, and … However, a better knowledge of cellular
and molecular mechanisms that … Ethyl pyruvate (EP) is an antioxidant ester form and can …

[PDF][PDF] Ischemia-reperfusion injury in a rat model of normothermic oxygenated machine perfusion and liver transplantation

X Chen - db-thueringen.de
… HMGB1 levels in serum increase during liver IRI as early as 1 h after reperfusion and …
recipients revealed that gender significantly affected post-transplant survival. Graft survival rate in …

Analysis of the potential ferroptosis mechanism and multitemporal expression change of central ferroptosis-related genes in cardiac ischemiareperfusion injury

Z Wang, Z He, Q Xuan, Y Zhang, J Xu, J Lin… - Frontiers in …, 2022 - frontiersin.org
… Although myocardial reperfusion is critical for ischemic cardiac tissue survival, the … The
subsequent analysis of these genes in this article helps reveal the potential biological pathway …

NRF2 Plays a Crucial Role in the Tolerogenic Effect of Ethyl Pyruvate on Dendritic Cells

S Stanisavljević, G Stegnjaić, B Jevtić… - International Journal of …, 2024 - mdpi.com
… in the maintenance of redox homeostasis [9] and counteracting the increase in intracellular
ROS [36]. During the increase in ROS generation in DCs, NRF2 translocates into the nucleus …

Effects of Borneol on Apoptosis in Hypoxia/Reoxygenation H9C2 Rat Cardiomyocytes

H Zhang, J Wen, J Zhang, H Xu, T Liu, Y Li - Authorea Preprints, 2022 - essopenarchive.org
… can alleviate cerebral ischemiareperfusion injury in rats by … liposome improves
cerebral ischemia reperfusion injury by … effects of ethyl pyruvate after regional ischaemia/reperfusion