Defining genomic, transcriptomic, proteomic, epigenetic, and phenotypic biomarkers with prognostic capability in male breast cancer: a systematic review

S Chatterji, E Krzoska, CW Thoroughgood… - The Lancet …, 2023 - thelancet.com
… that male and female breast cancer differ in their molecular landscapes. In this systematic
review, we consolidated all existing prognostic biomarker data in male breast cancer spanning …

[PDF][PDF] A critical review on: Comprehending breast cancer in men with reference to female

VA Vasudev, D Mutthuraj, GL Aruna, BM Kanthesh - researchgate.net
genes are the most well-known genetic abnormalities linked to this malignancy [39]. Situated
on chromosome 17, the BRCA1 gene … cases of breast cancer, the ERBB2 gene is amplified, …

Increased ERBB2 Gene Copy Numbers Reveal a Subset of Salivary Duct Carcinomas with High Densities of Tumor Infiltrating Lymphocytes and PD-L1 Expression

K Chatzopoulos, AR Collins, S Sotiriou… - Head and Neck …, 2020 - Springer
… underlying gene copy number alterations and we evaluatedChromosome 17 copy numbers
that are detected by FISH can … in breast cancer patients, even without concurrent ERBB2

[HTML][HTML] Dual-color dual-hapten in situ hybridization (D-DISH)–Comparison with fluorescence in situ hybridization (FISH) for HER2/neu testing in breast cancer

PK Gajaria, S Tambe, T Pai, A Patil… - Indian Journal of …, 2020 - journals.lww.com
… SPEC ERBB2 probe specific for the chromosomal region … We evaluated the HER2/neu gene
amplification status by D-… the discrepancy in evaluating chromosome 17 abnormalities in our …

[HTML][HTML] Prediction models for hormone receptor status in female breast cancer do not extend to males: further evidence of sex-based disparity in breast cancer

S Chatterji, JM Niehues, M van Treeck… - … Breast Cancer, 2023 - nature.com
… of BC, we evaluated the efficacy of attMIL pipelines in predicting ERα and PR status in both
… which could be predictive of the hormone receptor status of the tumor in H&E-stained slides. …

[HTML][HTML] HER2 heterogeneity and treatment response–associated profiles in HER2-positive breast cancer in the NCT02326974 clinical trial

Z Li, O Metzger Filho, G Viale… - The Journal of …, 2024 - Am Soc Clin Investig
ERBB2 FISH and heterogeneity assessment. Central pathology evaluation of HER2 status
was … to chromosome 17 centromeric probe [CEP17] ≥ 2 or ERBB2 copy number ≥ 6). HER2 …

Precision Medicine in Breast Cancer: A Molecular Genomics and Diagnostics Approach

H Dalal - 2024 - portal.research.lu.se
… classification and contribute to new biomarker assessment … By developing a refined
ddPCR assay for ERBB2 mRNA … in altered gene expression patterns, splicing anomalies, and …

[HTML][HTML] Breast cancer—epidemiology, classification, pathogenesis and treatment (review of literature)

B Smolarz, AZ Nowak, H Romanowicz - Cancers, 2022 - mdpi.com
gene, located on chromosome 17, is a suppressor gene that … of developing breast cancer
regardless of menopausal status. … These mutations, including NF1 loss and ERBB2 activating …

[HTML][HTML] ERBB2 FISH and Chromosome Microarray Testing of Gastroesophageal Adenocarcinomas at a Single Institution

A Yu, S Luikart, G Huang, S Han, J Zhao… - Cancer medicine …, 2020 - ncbi.nlm.nih.gov
… alone (eg, chromosome 17 ERBB2 gene locus), resulting in … most common abnormalities
in GEA and breast cancers, none … the value of CMA in GEA evaluation. Our study calls for the …

[HTML][HTML] Molecular perspective on targeted therapy in breast cancer: a review of current status

B Demir Cetinkaya, C Biray Avci - Medical Oncology, 2022 - Springer
… directly against molecular abnormalities or tumor cells that cause cancer development. The
… the tyrosine kinase of HER1, HER2 / ErbB2, and EGFR, subsequently prevents the receptor …