Systematic in silico Evaluation of Leishmania spp. Proteomes for Drug Discovery

CR dos Santos Vasconcelos, AM Rezende - Frontiers in Chemistry, 2021 - frontiersin.org
… of integrated computational methods capable of evaluating the … as the potential interaction
of the DEAD box RNA helicase, … Among these compounds inferred as antileishmanial in our …

Evaluation of target-specific natural compounds for drug discovery against leishmaniasis

V Gouri, S Upreti, M Samant - Parasitology International, 2022 - Elsevier
evaluation of specific natural inhibitors to overcome leishmaniasis. Hence, in this review, we
have discussed various specific targets … Therefore, evaluation of the DEAD BOX helicase as …

Recent advances on computational approach towards potential drug discovery against leishmaniasis

T Joshi, P Sharma, T Joshi, S Mathpal… - … and prevention of …, 2021 - Elsevier
… Further results of docking are evaluated by MD simulations. … techniques against molecular
targets of L. donovani. … for the set of compounds and checked their antileishmanial activity by …

Identification of potential inhibitors targeted for strengthening search of anti-leishmanial therapeutics

A Jha, S Verma, A Kumar - Biologia, 2020 - Springer
antileishmanial therapeutics. Likewise, in this study, we have … identification of the potential
compounds might impact and … Thus, according to computational values, Benzoxaborole was …

Unveiling the Targets Involved in the Quest of Antileishmanial Leads Using In silico Methods

PK Boniface, CM Sano, FI Elizabeth - Current Drug Targets, 2020 - ingentaconnect.com
… action of potent antileishmanial compounds. … Computational methods have been considered
as important … donovani DEAD-box RNA helicase (which is essential for RNA …

Synthesis, Evaluation of Leishmanicidal Activity Against Leishmania Amazonensis and 4d-Qsar Analysis of Vanillin-Containing 1, 2, 3-Triazole Derivatives

PAR Gazolla, WP Lima, AR de AGUIAR… - Evaluation of … - papers.ssrn.com
… the antileishmanial activity for those compoundscompounds presented different degrees
of efficacy on promastigotes. The most active compound 4b presented low cytotoxicity, targeted

DDX3 DEAD-box RNA helicase (Hel67) gene disruption impairs infectivity of Leishmania donovani and induces protective immunity against visceral leishmaniasis

SC Pandey, V Pande, M Samant - Scientific reports, 2020 - nature.com
… neglected tropical diseases that targets tissue macrophages. … Therefore to evaluate the role
of DEAD Box RNA Helicase … − null mutant it was further tested as a genetically modified live …

Leishmanicidal activity and 4D quantitative structure–activity relationship and molecular docking studies of vanillin-containing 1, 2, 3-triazole derivatives

PA Rodrigues Gazolla, WP Lima… - Future Medicinal …, 2024 - Taylor & Francis
targeting DEAD-box RNA helicase of Leishmania donovani, and vanillin was among the
selected ligands. This compound … This review details the antileishmanial effect of various plant …

Antimicrobial peptides, nanocarrier systems, and databases: Therapeutic platform against leishmaniasis

A Khusro, C Aarti, MUK Sahibzada - Natural Products in Vector-Borne …, 2023 - Elsevier
antileishmanial drugs by selecting potential targets in parasites. This chapter discusses
promising roles of AMPs, compounds/… VL cases from 16 countries were tested for HIV co-infection…

Drug resistance and repurposing of existing drugs in Leishmaniasis

A Paliwal, R Gahtori, A Kumari, P Pandey - Pathogenesis, Treatment and …, 2021 - Elsevier
… are being developed for the screening of antileishmanial compounds that are cost-effective, …
be rapidly evaluated. More combinatorial therapies of these potential antileishmanial agents …