Systematic in silico Evaluation of Leishmania spp. Proteomes for Drug Discovery
CR dos Santos Vasconcelos, AM Rezende - Frontiers in Chemistry, 2021 - frontiersin.org
… of integrated computational methods capable of evaluating the … as the potential interaction
of the DEAD box RNA helicase, … Among these compounds inferred as antileishmanial in our …
of the DEAD box RNA helicase, … Among these compounds inferred as antileishmanial in our …
Evaluation of target-specific natural compounds for drug discovery against leishmaniasis
V Gouri, S Upreti, M Samant - Parasitology International, 2022 - Elsevier
… evaluation of specific natural inhibitors to overcome leishmaniasis. Hence, in this review, we
have discussed various specific targets … Therefore, evaluation of the DEAD BOX helicase as …
have discussed various specific targets … Therefore, evaluation of the DEAD BOX helicase as …
Recent advances on computational approach towards potential drug discovery against leishmaniasis
… Further results of docking are evaluated by MD simulations. … techniques against molecular
targets of L. donovani. … for the set of compounds and checked their antileishmanial activity by …
targets of L. donovani. … for the set of compounds and checked their antileishmanial activity by …
Identification of potential inhibitors targeted for strengthening search of anti-leishmanial therapeutics
… antileishmanial therapeutics. Likewise, in this study, we have … identification of the potential
compounds might impact and … Thus, according to computational values, Benzoxaborole was …
compounds might impact and … Thus, according to computational values, Benzoxaborole was …
Unveiling the Targets Involved in the Quest of Antileishmanial Leads Using In silico Methods
PK Boniface, CM Sano, FI Elizabeth - Current Drug Targets, 2020 - ingentaconnect.com
… action of potent antileishmanial compounds. … Computational methods have been considered
as important … donovani DEAD-box RNA helicase (which is essential for RNA …
as important … donovani DEAD-box RNA helicase (which is essential for RNA …
Synthesis, Evaluation of Leishmanicidal Activity Against Leishmania Amazonensis and 4d-Qsar Analysis of Vanillin-Containing 1, 2, 3-Triazole Derivatives
PAR Gazolla, WP Lima, AR de AGUIAR… - Evaluation of … - papers.ssrn.com
… the antileishmanial activity for those compounds … compounds presented different degrees
of efficacy on promastigotes. The most active compound 4b presented low cytotoxicity, targeted …
of efficacy on promastigotes. The most active compound 4b presented low cytotoxicity, targeted …
DDX3 DEAD-box RNA helicase (Hel67) gene disruption impairs infectivity of Leishmania donovani and induces protective immunity against visceral leishmaniasis
… neglected tropical diseases that targets tissue macrophages. … Therefore to evaluate the role
of DEAD Box RNA Helicase … − null mutant it was further tested as a genetically modified live …
of DEAD Box RNA Helicase … − null mutant it was further tested as a genetically modified live …
Leishmanicidal activity and 4D quantitative structure–activity relationship and molecular docking studies of vanillin-containing 1, 2, 3-triazole derivatives
PA Rodrigues Gazolla, WP Lima… - Future Medicinal …, 2024 - Taylor & Francis
… targeting DEAD-box RNA helicase of Leishmania donovani, and vanillin was among the
selected ligands. This compound … This review details the antileishmanial effect of various plant …
selected ligands. This compound … This review details the antileishmanial effect of various plant …
Antimicrobial peptides, nanocarrier systems, and databases: Therapeutic platform against leishmaniasis
A Khusro, C Aarti, MUK Sahibzada - Natural Products in Vector-Borne …, 2023 - Elsevier
… antileishmanial drugs by selecting potential targets in parasites. This chapter discusses
promising roles of AMPs, compounds/… VL cases from 16 countries were tested for HIV co-infection…
promising roles of AMPs, compounds/… VL cases from 16 countries were tested for HIV co-infection…
Drug resistance and repurposing of existing drugs in Leishmaniasis
A Paliwal, R Gahtori, A Kumari, P Pandey - Pathogenesis, Treatment and …, 2021 - Elsevier
… are being developed for the screening of antileishmanial compounds that are cost-effective, …
be rapidly evaluated. More combinatorial therapies of these potential antileishmanial agents …
be rapidly evaluated. More combinatorial therapies of these potential antileishmanial agents …