Weight of evidence for cross-species conservation of androgen receptor-based biological activity
… considering in vitro high-throughput screening assays to screen … results can be extrapolated
across taxa. To assess the … weight of evidence for cross-species extrapolation and provides …
across taxa. To assess the … weight of evidence for cross-species extrapolation and provides …
Combination of computational new approach methodologies for enhancing evidence of biological pathway conservation across species
… to support cross-species extrapolation of chemical toxicity … In this way, high-throughput
screening data from either … of potential chemical susceptibility, the results from the combined …
screening data from either … of potential chemical susceptibility, the results from the combined …
Critical review of read‐across potential in testing for endocrine‐related effects in vertebrate ecological receptors
ME McArdle, EL Freeman, JP Staveley… - Environmental …, 2020 - Wiley Online Library
… tools and approaches that support species extrapolation for fish, … The growing availability of
high-throughput (HTP) screening … body of mammalian-based HTP data available from testing …
high-throughput (HTP) screening … body of mammalian-based HTP data available from testing …
Demonstration of the sequence alignment to predict across species susceptibility tool for rapid assessment of protein conservation
… different applications for cross-species extrapolation. … , including high-throughput screening
assays, high-throughput … data interpretation for predictions of cross-species susceptibility. …
assays, high-throughput … data interpretation for predictions of cross-species susceptibility. …
Cross-species molecular docking method to support predictions of species susceptibility to chemical effects
… results of this study and previous work that focused on cross-species extrapolation using AR
[24], [34]. … line of evidence as part of a weight of evidence approach to support predictions of …
[24], [34]. … line of evidence as part of a weight of evidence approach to support predictions of …
Leveraging ToxCast data and protein sequence conservation to complement aquatic life criteria derivation
… was to assess the pertinence of mammalian-based NAM data to … , transformation, and
extrapolation were required to achieve … High-throughput screening in cell lines that display even …
extrapolation were required to achieve … High-throughput screening in cell lines that display even …
[HTML][HTML] In vitro assessment of thyroid peroxidase inhibition by chemical exposure: comparison of cell models and detection methods
R Liu, J Novák, K Hilscherová - Archives of Toxicology, 2024 - Springer
… used assays applicable for high throughput screening [Luminol … Extrapolation of toxicity
data from model species to other … activity, whilst the results of Luminol assay are not specific to …
data from model species to other … activity, whilst the results of Luminol assay are not specific to …
Comparison of in silico, in vitro, and in vivo toxicity benchmarks suggests a role for ToxCast data in ecological hazard assessment
CM Schaupp, EM Maloney, KZ Mattingly… - Toxicological …, 2023 - academic.oup.com
… to reliably extrapolate concentrations from a ToxCast assay to … contribute to weight-of-evidence
indicating the likelihood of a … mammalian‐based high throughput screening assay results …
indicating the likelihood of a … mammalian‐based high throughput screening assay results …
Assessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo
… one cannot conclude whether HTS results are the primary mode-… issue, high throughput
screening (HTS) assays have been … which confounds extrapolation of bioactivity across species. …
screening (HTS) assays have been … which confounds extrapolation of bioactivity across species. …
Evaluation of a multiplexed, multispecies nuclear receptor assay for chemical hazard assessment
… purposes and screening level approaches and is very high throughput; however, empirical
… experimental results with in silico values, allowing for cross-species extrapolation well …
… experimental results with in silico values, allowing for cross-species extrapolation well …