… Literature provides pieces of evidence about normal and leukemic bone … for maintaining
the architecture of the microenvironment and regulating HSCs behavior. The platelet endothelial …

… The bone is also the primary site where blood cancer begins, … Recent evidence suggests
that the interaction between … trabecular scaffold that after a maintenance phase, was placed …

… involved in the maintenance of the leukaemic niche. … evidence also suggests that leukaemic
cell-secreted inflammatory mediators are pivotal in regulating the expression of endothelial …

… of SCF in promoting HSPC maintenance in the perivascular … evidence indicates that both
leukaemic and leukaemic stem … -culture of leukaemia cells with bone marrow-derived stromal …

… evidence shows the presence of heterogenic blood vessel … of various bone marrow–derived
mesenchymal cell types to … approaches to treat leukemia and other bone malignancies. …

… changes in stromal bone marrow-derived cells, causing … to evidence that IGF-1/IGF-1R
signaling exerts pro-leukemic … 1α is required for the maintenance of leukemia-initiating cells in …

… on interactions with MSCs and arteriole endothelial cells via various proteins, … leukaemic
cells are the main source of inflammatory mediators in MDS and AML. Experimental models …

… 1F), and the density of CD34 and CD144 [Vascular Endothelial … of endothelial growth factor
support to generate organoid … MSCs in homing and maintenance of HSPCs to perivascular …

… and maintenance in the BM [28]. Arterial blood vessel endothelial cells, thanks to their low
… In support of this hypothesis, there is evidence that not only leukemic cells, but also normal …

… mouse models, studies have provided anatomical evidence of … cell-derived SCF was required
for HSC maintenance and … in a mouse model of BCR-ABL1 + B-ALL, where leukemic cells …