[HTML][HTML] Somatostatin, a presynaptic modulator of glutamatergic signal in the central nervous system

A Pittaluga, A Roggeri, G Vallarino… - International Journal of …, 2021 - mdpi.com
… innervating the septum, the striatum, the hippocampus and the … somatostatin immunoreactivity
was high, the sst2 receptorsevidence was published demonstrating that somatostatin

A role for the neuropeptide somatostatin in the neurobiology of behaviors associated with substances abuse and affective disorders

SL Robinson, TE Thiele - Neuropharmacology, 2020 - Elsevier
… We further summarize evidence of a direct role for the SST … observed in this study was
mediated by an increase in CeA SST … infusion increases striatal dopamine release via presynaptic …

Structure and Function of Somatostatin and its Receptors in Endocrinology

B Zhang, L Xue, ZB Wu - Endocrine Reviews, 2024 - academic.oup.com
… with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory
… Selective regulation of somatostatin receptor subtype signaling: evidence for constitutive …

Somatostatin and Neurotensin Systems in Schizophrenia

A Induni, F Gil Zbinden, MG López Ordieres - Psychiatry and Neuroscience …, 2021 - Springer
receptors mediate the inhibition of insulin secretion, and the sst2 receptor seems to mediate
… a culture of dopaminergic neurons, it has been enabled to prove a bidirectional interaction …

[HTML][HTML] Somatostatin peptide signaling dampens cortical circuits and promotes exploratory behavior

DF Brockway, KR Griffith, CM Aloimonos, TT Clarity… - Cell reports, 2023 - cell.com
We sought to characterize the unique role of somatostatin (SST) in the prelimbic (PL) cortex
in mice. We performed slice electrophysiology in pyramidal and GABAergic neurons to …

Activation of dopamine D2 receptor promotes pepsinogen secretion by suppressing somatostatin release from the mouse gastric mucosa

XY Liu, LF Zheng, YY Fan, QY Shen… - … of Physiology-Cell …, 2022 - journals.physiology.org
… pepsinogen secretion directly through D1-like receptors on chief … D 2 R-mediated suppression
of somatostatin release. … brain striatum medium spiny neurons (81, 82) and the receptors

[HTML][HTML] Excitatory SST neurons in the medial paralemniscal nucleus control repetitive self-grooming and encode reward

J Sun, Y Yuan, X Wu, A Liu, J Wang, S Yang, B Liu… - Neuron, 2022 - cell.com
… Here, we identify that the excitatory somatostatin-positive neurons in the medial … activating
dopamine (DA) neurons in the ventral tegmental area (VTA) and eliciting dopamine release. …

[HTML][HTML] Altered expression of somatostatin signaling molecules and clock genes in the hippocampus of subjects with substance use disorder

J Valeri, SM O'Donovan, W Wang, D Sinclair… - Frontiers in …, 2022 - frontiersin.org
… of somatostatin in subjects with substance use disorder and in subjects with major depression.
We also observed increased somatostatin receptor … first evidence for altered somatostatin

Differential expression of five prosomatostatin genes in the central nervous system of the catshark Scyliorhinus canicula

D Sobrido‐Cameán, H Tostivint… - Journal of …, 2020 - Wiley Online Library
… contribution of each somatostatin to specific … evidence in late catshark embryos of a cell
migratory route from the medial ganglionic eminence homolog invading the prospective striatal

[HTML][HTML] Agonists, Antagonists and Receptors of Somatostatin: Pathophysiological and Therapeutical Implications in Neoplasias

A Periferakis, G Tsigas, AT Periferakis… - Current Issues in …, 2024 - mdpi.com
… On the other hand, a number of somatostatin antagonists may prove useful in certain medical
settings, based on their differential affinity for SSTRs. The aim of this review is to present in …