… 5-formylcytosine (5-fC) and 5-carboxylcytosine (5-caC). 5-fC … excised by the base excision
repair (BER) protein Thymine … terminal domain, whereas its carboxyl terminal domain has an …

… undergo oxidation, generating 5-hydroxymethyluracil (5hmU), 5… to be substrates for Thymine
DNA glycosylase [46]. This … sites generated by glycosylase excision. Oligonucleotides were …

… bases sensors for the base excision repair (BER) pathway. … , with a special focus on 5-hydroxymethyluracil,
can affect the … ), 5-formylcytosine (5-fC), and 5-carboxylcytosine (5-caC), all …

… DNA bases and initiate the base excision repair (BER) … Thymine DNA glycosylase (TDG),
which belongs to family 2 … DNA glycosylase UDGX to abasic DNA upon uracil excision. …

… In the first step of the base excision repair system, glycosylases such as human thymine
DNA glycosylase recognize a damaged or mispaired base and remove it via glycosidic C1′-N1 …

… , excision of fC or caC by thymine-DNA glycosylase (TDG), and subsequent base excision …
The crystal structure of TDG in complex with substrate 5-carboxylcytosine (PDB ID 3uo7) and …

… thymine-DNA glycosylase (TDG) was initially discovered as an enzymatic activity excising
… T, U, 5-fluorouracil and 5-hydroxymethyluracil in a XpG context from duplex DNA [33,46,47]. …

… -DNA glycosylase TDG [20], and possibly UNG, by removing 5-carboxylcytosine from DNA
… also has a distinct function in the removal of 5-hydroxymethyluracil in vivo [10]. Furthermore, …

… domain, which can bind CpG with various epigenetic modifications. … 5-carboxylcytosine
(caCyt), or by deamination of the oxidized mCyt bases to the corresponding Ura series. Excision …

… , DNA glycosylases initiate repair by detecting and excising … converted by AID/APOBEC to
5-hydroxymethyluracil (5-hmU), … and JMJD2A (Jumonji domain containing 2A) generates an …