Why the HIV reservoir never runs dry: clonal expansion and the characteristics of HIV-infected cells challenge strategies to cure and control HIV infection
CY Lau, MA Adan, F Maldarelli - Viruses, 2021 - mdpi.com
… the mechanisms of HIV-1 persistence and clonal expansion, … T cells harboring
replication-competent latent HIV-1 was low (… time points revealed that some clones wax and wane …
replication-competent latent HIV-1 was low (… time points revealed that some clones wax and wane …
The forces driving clonal expansion of the HIV-1 latent reservoir
… by expanded clones carrying replication-competent proviruses, … Of note, cells harboring
replication competent HIV-1 died of viral … , and only defective proviral clones were identified. The …
replication competent HIV-1 died of viral … , and only defective proviral clones were identified. The …
The clonal expansion dynamics of the HIV-1 reservoir: mechanisms of integration site-dependent proliferation and HIV-1 persistence
… few clones of HIV-1, known as the predominant plasma clones … matched cellular RNA aliquots
are used for targeted HIV-1 … clonally expanded replication-competent HIV-1 [68] and HIV-1 …
are used for targeted HIV-1 … clonally expanded replication-competent HIV-1 [68] and HIV-1 …
The impact of cellular proliferation on the HIV-1 reservoir
MC Virgilio, KL Collins - Viruses, 2020 - mdpi.com
… cells carrying defective proviruses can clonally expand [7], cells with replication-competent …
, the quantity of cellular clones with intact, replication-competent provirus, and sometimes …
, the quantity of cellular clones with intact, replication-competent provirus, and sometimes …
The role of clonally expanded HIV-1 infected cells in maintaining HIV reservoirs in adults and children on antiretroviral treatment
JC Botha - 2020 - scholar.sun.ac.za
… were shown to be replication competent by viral outgrowth. … The capsid-p24 protein is crucial
for virion formation and carrying … For this study, 30 of the most expanded clones from the 11 …
for virion formation and carrying … For this study, 30 of the most expanded clones from the 11 …
Genotypic and phenotypic diversity of the replication-competent HIV reservoir in treated patients
A Nicolas, J Migraine, J Dutrieux, M Salmona… - Microbiology …, 2022 - Am Soc Microbiol
… phylogenetic tree of replication-competent HIV-1 isolates. … the MPD counting each series of
clones as a single sequence. By … clonally expanded cells carrying replication-competent viral …
clones as a single sequence. By … clonally expanded cells carrying replication-competent viral …
Dynamics of latent HIV under clonal expansion
JM Murray - PLoS Pathogens, 2021 - journals.plos.org
… of cellular activation and proliferation, we were able to show that activation can expand clone
… Babiker A., Darby S., De Angelis D., Kwart D., Porter K., Beral V., et al., Time from HIV-1 …
… Babiker A., Darby S., De Angelis D., Kwart D., Porter K., Beral V., et al., Time from HIV-1 …
Nonsuppressible HIV-1 viremia: a reflection of how the reservoir persists
JD Siliciano, RF Siliciano - The Journal of Clinical …, 2020 - Am Soc Clin Investig
… be due to expanded clones of infected CD4 + T cells carrying replication-competent virus.
The … At least some cells comprising the expanded cellular clones described here (1) produced …
The … At least some cells comprising the expanded cellular clones described here (1) produced …
HIV infected CD4+ T cell clones are more stable than uninfected clones during long-term antiretroviral therapy
S Guo, BT Luke, AR Henry, S Darko, LD Brandt… - PLoS …, 2022 - journals.plos.org
… years, clones that carry replication-competent proviruses can … of drug resistance, had
persistent levels of HIV-1 RNA in the … of the integration sites were in clones of expanded cells. As …
persistent levels of HIV-1 RNA in the … of the integration sites were in clones of expanded cells. As …
Antigen-driven clonal selection shapes the persistence of HIV-1–infected CD4+ T cells in vivo
FR Simonetti, H Zhang, GP Soroosh… - The Journal of …, 2021 - Am Soc Clin Investig
… that CD4 + T cell clones carrying an inducible replication-competent provirus can be selected
… To understand the extent of expansion of these HIV-1–infected, CMV-specific clones, we …
… To understand the extent of expansion of these HIV-1–infected, CMV-specific clones, we …