Explore of the beneficial effects of Huang-Lian-Jie-Du Decoction on diabetic encephalopathy in db/db mice by UPLC-Q-Orbitrap HRMS/MS based untargeted …

WJ He, DM Cao, YB Chen, JJ Shi, T Hu… - … of Pharmaceutical and …, 2021 - Elsevier
… mellitus and Alzheimer's disease in clinical practices, however, the therapeutic effects and the
… analysis were estimated to assess the beneficial effects of HLJDD on DE. Plasma samples …

Therapeutic effect and mechanism of Anemarrhenae Rhizoma on Alzheimer's disease based on multi-platform metabolomics analyses

H Wang, JY Dai, YZ He, ZW Xia, XF Chen… - Frontiers in …, 2022 - frontiersin.org
… the effect and its molecular mechanism are not elucidated clear. This study aims to evaluate
AR’s therapeutic effect and … Behavior study, histopathological observations, and biochemical …

Huanglian Jiedu decoction remodels the periphery microenvironment to inhibit Alzheimer's disease progression based on the “brain-gut” axis through multiple …

X Gu, J Zhou, Y Zhou, H Wang, N Si, W Ren… - Alzheimer's Research & …, 2021 - Springer
… Recently, excellent results on the pharmacological effects of HLJDD or its components have
study, the central neuroinflammation was closely related to the onset of AD. The disorders in …

Neuroprotective Mechanisms and Metabolomics Analysis of Jiedu Yizhi Formula in Alzheimer's Disease

Y Li, J Yan, T Cui, D Chen, X Zhu, J Wang, X Zhang… - 2024 - researchsquare.com
study:We studied the metabolites in the brain tissue of Alzheimer's Disease (AD) transgenic
mice to investigate … , we have effectively illustrated the neuroprotective effect of JDYZF on AD …

Involvement of Huanglian Jiedu decoction on microglia with abnormal sphingolipid metabolism in Alzheimer's disease

…, ZY Yao, SY Qu, PY Ge, X Zhao, S Ni… - Drug Design …, 2023 - Taylor & Francis
… This study provides a novel perspective on the potential roles of the sphingolipid … To
investigate the effects of HLJDD on the activation of BV2 cells stimulated by Aβ 25-35 , the …

… on UHPLC-LTQ–Orbitrap and network pharmacology approaches to explore the potential mechanism of Lycium ruthenicum Murr. for ameliorating Alzheimer's disease

Z Luo, G Yu, X Chen, Y Liu, Y Zhou, G Wang, Y Shi - Food & function, 2020 - pubs.rsc.org
… (LRM), a unique traditional Tibetan medicine, exerts beneficial effects on ameliorating learning
and memory deficits of Alzheimer's disease (AD) and other neurodegenerative disorders. …

Integrated brain and plasma dual-channel metabolomics to explore the treatment effects of Alpinia oxyphyllaFructus on Alzheimer's disease

Z Sun, Y Zhang, M Zhang, S Zhou, W Cheng, L Xue… - Plos one, 2023 - journals.plos.org
… and memory defects of Alzheimers disease for many years. … study, we used a rat Alzheimers
disease model on intrahippocampal injection of aggregated Aβ 1–42 to study the effects of …

Yuan-Zhi decoction in the treatment of Alzheimer's disease: An integrated approach based on chemical profiling, network pharmacology, molecular docking and …

Q Wu, X Li, XW Jiang, D Yao, LJ Zhou, ZH Xu… - Frontiers in …, 2022 - frontiersin.org
… with demonstrated clinical benefits in Alzheimers disease (AD). We used … study provides
scientific support for the clinical use of YZD and justifies further investigations into its effects

Mechanism of Huang-lian-Jie-du decoction and its effective fraction in alleviating acute ulcerative colitis in mice: Regulating arachidonic acid metabolism and …

Z Yuan, L Yang, X Zhang, P Ji, Y Hua, Y Wei - Journal of …, 2020 - Elsevier
… , stroke, Alzheimer's disease and gastrointestinal diseases. Our … The aim of this study is to
further investigate the mechanism … modeling and the intervention effect of HLJDD and HLJDD-…

Comprehensive analysis of Huanglian Jiedu decoction: Revealing the presence of a self-assembled phytochemical complex in its naturally-occurring precipitate

M Chen, P Wang, T Li, L Li, J Li, H Bai, H Lei… - Journal of Pharmaceutical …, 2021 - Elsevier
… This study provides fundamental scientific evidence of the … silanol effects and providing
improved column performance. The … arthritis in rats after treatment with Huang-Lian-Jie-Du-Tang