Modeling extracellular matrix-cell interactions in lung repair and chronic disease

TL Hackett, ET Osei - Cells, 2021 - mdpi.com
… of chronic lung diseases such as COPD, lung cancer and IPF, … In summary, ECM remodeling
in COPD affects both … of ECM components directly, or the production of ECM remodeling

Therapeutic targets in lung tissue remodelling and fibrosis

G Liu, AM Philp, T Corte, MA Travis, H Schilter… - Pharmacology & …, 2021 - Elsevier
pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF)… Abnormal deposition of
extracellular matrix (ECM) proteins isremodelling that results in symptoms and impaired lung

Interplay between extracellular matrix and neutrophils in diseases

Y Zhu, Y Huang, Q Ji, S Fu, J Gu, N Tai… - Journal of immunology …, 2021 - Wiley Online Library
… ECM remodeling by providing specific matrix-remodelingcomponents are associated with
the course of many chronic inflammatory diseases, especially several chronic lung diseases, …

The lung extracellular matrix protein landscape in severe early-onset and moderate chronic obstructive pulmonary disease

MM Joglekar, NJ Bekker… - … -Lung Cellular and …, 2023 - journals.physiology.org
Extracellular matrix (ECM) remodeling has been implicated in … in chronic obstructive pulmonary
disease (COPD). Studies 38 … the component scores for each component between COPD

Granzyme B in inflammatory diseases: apoptosis, inflammation, extracellular matrix remodeling, epithelial-to-mesenchymal transition and fibrosis

F Velotti, I Barchetta, FA Cimini… - Frontiers in immunology, 2020 - frontiersin.org
… of cleaving extracellular matrix (ECM) components, … - has been reported in inflammatory
pulmonary diseases, including age-related diseases, as COPD (23, 38), and acute severe lung

Extracellular matrix-derived peptides in tissue remodeling and fibrosis

LE de Castro Brás, NG Frangogiannis - Matrix biology, 2020 - Elsevier
… The extracellular matrix (ECM) is the non-cellular component … PGP levels were reported
to directly correlate with disease … of lung conditions, including chronic obstructive pulmonary

Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases

KEC Blokland, SD Pouwels, M Schuliga… - Clinical …, 2020 - portlandpress.com
conditions arise from aberrant matrix remodelling during … response observed in these lung
diseases; possibly by hindering re-… Caspase-1 has been identified as part of the SASP and is

The extracellular matrix and mechanotransduction in pulmonary fibrosis

Z Deng, MW Fear, YS Choi, FM Wood… - The international journal …, 2020 - Elsevier
problems and in some diseases, death. It includes several lung disorders with idiopathic
pulmonary … stage fibrotic remodelling, but that ECM components also drive disease progression. …

Fibroblasts: The arbiters of extracellular matrix remodeling

KY DeLeon-Pennell, TH Barker, ML Lindsey - Matrix Biology, 2020 - Elsevier
… a wide range of disease. We highlight here fibroblast roles in the cancer, lung, and heart as
… specific ECM components such as fibrinogen which is elevated in lung fibrosis compared to …

Link between increased cellular senescence and extracellular matrix changes in COPD

RR Woldhuis, M de Vries, W Timens… - … -Lung Cellular and …, 2020 - journals.physiology.org
… Chronic obstructive pulmonary disease (COPD) is … , part of these effects was more pronounced
in SEO-COPD. With … peripheral lung and contribute to lung tissue remodeling and small …