Increased myofibroblasts in the small airways, and relationship to remodelling and functional changes in smokers and COPD patients: potential role of epithelial …

MS Eapen, W Lu, TL Hackett, GK Singhera… - ERJ open …, 2021 - Eur Respiratory Soc
… and altered extracellular matrix (ECM). Here we relate small … ”-like population was the largest
cell component [6, 7]. In the … Subjects with other respiratory diseases, a history of a recent …

[HTML][HTML] Neutrophil elastase and chronic lung disease

JA Voynow, M Shinbashi - Biomolecules, 2021 - mdpi.com
… NE exposure induces airway remodeling with increased mucin … target NE in chronic lung
diseases, and alternative strategies … , NE protease activity degrades extracellular matrix (ECM) …

[HTML][HTML] Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis

J Yang, X Pan, L Wang, G Yu - Molecular Medicine, 2020 - Springer
… and excessive deposition of extracellular matrix, which result in a … remodeling which alter
cellular mechanical forces. It … lung diseases, is characterized by excessive deposition of …

Extracellular Matrix in Vascular Disease, Part 2/4: JACC Focus Seminar

J Barallobre-Barreiro, B Loeys, M Mayr… - Journal of the American …, 2020 - jacc.org
… Of all fibulins that have been reported to contribute to … often present with lung emphysema,
FBLN4 deficiency is … in individual components will induce secondary remodeling processes …

[HTML][HTML] The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation

L Moretti, J Stalfort, TH Barker, D Abebayehu - Journal of Biological …, 2022 - ASBMB
… become increasingly necessary to consider them as parts of … , inflammation, repair, and
remodeling) against the backdrop of … fibroproliferative diseases, such as idiopathic pulmonary

Bidirectional interaction of airway epithelial remodeling and inflammation in asthma

A Banno, AT Reddy, SP Lakshmi, RC Reddy - Clinical science, 2020 - portlandpress.com
Airway remodeling and resulting pulmonary dysfunction arise … as prominent sources of
extracellular matrices (ECMs), … be important to determine how other components of airway

Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome

S Holm Nielsen, L Jonasson… - Journal of internal …, 2020 - Wiley Online Library
… This review will focus on ECM remodelling in plaque vulnerability … components, MMP
zymogens and inflammatory mediators. MMP-7 mRNA and protein expression have been detected

[HTML][HTML] Non-coding RNAs modulate function of extracellular matrix proteins

NA Dilmaghnai, H Shoorei, G Sharifi, M Mohaqiq… - Biomedicine & …, 2021 - Elsevier
… defined by several parameters that regulate the production and turnover of each ECM element
Asthma has been associated with the remodeling of the airways by airway smooth muscle …

[HTML][HTML] The role of the ECM in lung cancer dormancy and outgrowth

AL Parker, TR Cox - Frontiers in oncology, 2020 - frontiersin.org
… We will focus on the role of the lung extracellular matrix in … extracellular matrix remodeling
in chronic lung diseases … should include extracellular matrix components that also modulate …

[HTML][HTML] Collagen biosynthesis, processing, and maturation in lung ageing

C Onursal, E Dick, I Angelidis, HB Schiller… - Frontiers in …, 2021 - frontiersin.org
… scaffold, the extracellular matrix (ECM) is a critical regulator of cell … Collagen is the main
ECM component and hence plays an … It is well-established that many chronic lung diseases, eg, …