[HTML][HTML] Fibroageing: An ageing pathological feature driven by dysregulated extracellular matrix-cell mechanobiology

M Selman, A Pardo - Ageing Research Reviews, 2021 - Elsevier
remodelling. The scarring process characterized by excessive production and chaotic
accumulation of extracellular matrix (ECM) components… Moreover, in other interstitial lung diseases

Lung fibrosis and fibrosis in the lungs: is it all about myofibroblasts?

E Ortiz-Zapater, J Signes-Costa, P Montero, I Roger - Biomedicines, 2022 - mdpi.com
extracellular matrix (ECM) components such as collagen and fibronectin … extracellular
matrix remodeling on airflow obstruction in a rat model of chronic obstructive pulmonary disease

Linking oxidative stress and DNA damage to changes in the expression of extracellular matrix components

SG Martins, R Zilhão, S Thorsteinsdóttir… - Frontiers in …, 2021 - frontiersin.org
… that is affected by oxidative stress and DNA damage is extracellular matrix (ECM) remodeling,
which is … The crosstalk between oxidative stress/DNA damage and ECM remodeling is not …

Exuberant fibroblast activity compromises lung function via ADAMTS4

DF Boyd, EK Allen, AG Randolph, XJ Guo, Y Weng… - Nature, 2020 - nature.com
… states, which we term extracellular matrix (ECM)-synthesizing, … Therapeutic targets include
components of the lung ECM, … lung injury, ECM proteases are upregulated and remodel the …

The roles of matrix metalloproteinases and their inhibitors in human diseases

GA Cabral-Pacheco, I Garza-Veloz… - International journal of …, 2020 - mdpi.com
… that have the capacity to degrade almost every component of … coordination of extracellular
matrix remodeling with epithelial … a group of progressive lung diseases, most commonly …

Emerging roles of ECM remodeling processes in cancer

V Mohan, A Das, I Sagi - Seminars in cancer biology, 2020 - Elsevier
… breast, lung, and ovarian tissue, there is enhanced secretion … interaction between extracellular
matrix components and host … this review, it is clear that extracellular matrix is the medium …

Extracellular vesicles: novel communicators in lung diseases

A Mohan, S Agarwal, M Clauss, NS Britt… - Respiratory research, 2020 - Springer
… We also explore the role EVs can potentially serve as therapeutics for these lung diseases
when … the extracellular matrix proteins of the alveoli leading to the development of COPD like …

The leading role of epithelial cells in the pathogenesis of idiopathic pulmonary fibrosis

M Selman, A Pardo - Cellular signalling, 2020 - Elsevier
… progressive fibrotic lung disorders) have been focused on … to the abnormal extracellular
matrix remodeling. Interestingly, … key components of the hedgehog pathway in lung fibroblasts …

Progress in the Study of Fra-2 in Respiratory Diseases

S Zheng, Y Liu - International Journal of Molecular Sciences, 2024 - mdpi.com
extracellular matrix [10]. Moreover, Fra-2 Tg mice exhibited significant vascular remodeling
in their pulmonary … Additionally, research has indicated that Fra-2 plays a significant part in …

Mesenchymal stromal cell-derived extracellular vesicles in lung diseases: current status and perspectives

SC Abreu, M Lopes-Pacheco, DJ Weiss… - Frontiers in Cell and …, 2021 - frontiersin.org
… This growth factor has the ability to stimulate deposition of extracellular matrix components
by … inflammation and remodeling in several animal models and holds therapeutic promise for …