The functional role of extracellular matrix proteins in cancer

NV Popova, M Jücker - Cancers, 2022 - mdpi.com
… regulate matrix remodeling, but in cancer, the tumor matrix also … aims to present the functional
role of ECM components in … It was also found that exogenous fibronectin stimulates lung

Extracellular Matrix in Ischemic Heart Disease, Part 4/4: JACC Focus Seminar

NG Frangogiannis, JC Kovacic - Journal of the American College of …, 2020 - jacc.org
… Extensive evidence in models of pulmonary inflammation … in part) by targeting the ECM
network. However, the implementation of direct approaches to target matrix remodeling has been

Necroptosis signaling promotes inflammation, airway remodeling, and emphysema in chronic obstructive pulmonary disease

Z Lu, HP Van Eeckhoutte, G Liu, PM Nair… - … journal of respiratory …, 2021 - atsjournals.org
… of the core necrosome components RIPK3 and MLKL in clinical COPD lung tissue samples
and demonstrate … Mmp12 is an enzyme that breaks down the extracellular matrix that can …

[HTML][HTML] Downregulation of epithelial DUOX1 in chronic obstructive pulmonary disease

C Schiffers, C van de Wetering, RA Bauer… - JCI insight, 2021 - ncbi.nlm.nih.gov
… for lung tissue remodeling in mouse models of COPD. Small … evaluated lung tissue mRNA
expression of extracellular matrixpresent studies we show that acrolein, a major component of …

[HTML][HTML] The role of extracellular matrix in biomechanics and its impact on bioengineering of cells and 3D tissues

M Urbanczyk, SL Layland, K Schenke-Layland - Matrix Biology, 2020 - Elsevier
… in order to remodel the surrounding extracellular matrix. (For … example of viscoelastic ECM
components as their molecules … It has been reported that this lung ECM temporally regulates …

Extracellular matrix in heart failure: role of ADAMTS5 in proteoglycan remodeling

J Barallobre-Barreiro, T Radovits, M Fava, U Mayr… - Circulation, 2021 - Am Heart Assoc
Extracellular matrix (ECM) remodeling is a key pathologic feature of heart failure (HF). Once
initiated, ECM remodeling is … (serum amyloid P-component). C, Volcano plot comparing …

Emerging role of extracellular vesicles in the respiratory system

J Holtzman, H Lee - Experimental & Molecular Medicine, 2020 - nature.com
… in the respiratory system and outlines the pulmonary disease states … the extracellular matrix
and causes alveolar destruction in the … COPD is also characterized by airway remodeling and …

Pulmonary fibrosis as a result of acute lung inflammation: molecular mechanisms, relevant in vivo models, prognostic and therapeutic approaches

IA Savin, MA Zenkova, AV Sen'kova - International journal of molecular …, 2022 - mdpi.com
Pulmonary fibrosis is a chronic progressive lung disorder, … , changes in extracellular matrix
components and breach of … therapeutic targets of lung tissue remodeling and fibrogenesis. …

Skeletal muscle extracellular matrix–what do we know about its composition, regulation, and physiological roles? A narrative review

R Csapo, M Gumpenberger, B Wessner - Frontiers in physiology, 2020 - frontiersin.org
… Main components of the skeletal muscle extracellular matrix and its linkage to the contractile
Extracellular matrix remodeling may also be associated with metabolic disorders, such as …

Fibroblast heterogeneity and its impact on extracellular matrix and immune landscape remodeling in cancer

M Yamauchi, DL Gibbons, C Zong, JJ Fradette… - Matrix biology, 2020 - Elsevier
… gene expression signature that is specific to locale (eg, breast tumor or lung metastasis), …
molecules during remodeling could explain in part why the major ECM components, fibrillar …