Extracellularmatrix‐reinforced bioinks for 3D bioprinting human tissue

MM De Santis, HN Alsafadi, S Tas… - Advanced …, 2021 - Wiley Online Library
… ligands, individual extracellular matrix (ECM) components, or … that rECM bioinks containing
lung dECM can be used to 3D … this has been shown to correlate with remodeling outcomes …

Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway

B Ng, SA Cook, S Schafer - Experimental & Molecular Medicine, 2020 - nature.com
… amounts of extracellular matrix (ECM) in the lung interstitium, … 11 in the context of lung diseases
and pulmonary fibrosis, with a … is associated with increased pulmonary artery remodeling

Biological therapies of severe asthma and their possible effects on airway remodeling

G Kardas, P Kuna, M Panek - Frontiers in immunology, 2020 - frontiersin.org
is a change of composition, content and distribution of cellular and molecular components in
the airway … reduced the expression of three extracellular matrix proteins: tenascin, lumican …

Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in myofibroblast differentiation

DL Matera, KM DiLillo, MR Smith, CD Davidson… - Science …, 2020 - science.org
… Although the extracellular matrix becomes increasingly stiff … of physical and biochemical
matrix remodeling to fibrogenesis, … pulmonary disease and nonidiopathic fibrotic lung diseases

Lung tissue extracellular matrix‐derived hydrogels protect against radiation‐induced lung injury by suppressing epithelial–mesenchymal transition

J Zhou, P Wu, H Sun, H Zhou… - Journal of Cellular …, 2020 - Wiley Online Library
have a positive effect on the promotion of ECM hydrogel materials in the treatment of lung
diseases, and provide new ideas for protecting lungcomponents of the extracellular matrix (…

NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling

X Unamuno, J Gómez-Ambrosi, B Ramírez… - Cellular & molecular …, 2021 - nature.com
… 98 subjects were used in a case−control study. The expression of different components of …
associated with IL-1R/MyD88 signaling in the development of fibrosis both in lung and liver in …

[HTML][HTML] Extensive remodeling of the extracellular matrix during aging contributes to age-dependent impairments of muscle stem cell functionality

SC Schüler, JM Kirkpatrick, M Schmidt, D Santinha… - Cell reports, 2021 - cell.com
… intrinsic changes in the MuSC proteome and remodeling of the MuSC niche during aging.
We generate a network connecting age-affected ligands located in the niche and cell surface …

Into the tissues: Extracellular matrix and its artificial substitutes: Cell signalling mechanisms

A Bandzerewicz, A Gadomska-Gajadhur - Cells, 2022 - mdpi.com
… and are major extracellular matrix components. The basic … , leading to cardiovascular
disease, lung disease or typical … of the extracellular matrix undergoes continuous remodelling, …

Neutrophil extracellular traps in chronic lung disease: implications for pathogenesis and therapy

HR Keir, JD Chalmers - European Respiratory Review, 2022 - Eur Respiratory Soc
disease outcomes across the spectrum of airway diseases. … airway inflammation, airflow
obstruction, airway remodelling … chronic lung diseases, neutrophils are still a vital component of …

Metabolic dysregulation in idiopathic pulmonary fibrosis

E Bargagli, RM Refini, M d'Alessandro… - International journal of …, 2020 - mdpi.com
… with progressive extracellular matrix deposition in the lung … with other interstitial lung diseases.
Serum amyloid A proved to … vasoconstriction and vascular remodelling. Indeed, hypoxia …