… FGF21-based drugs have been performed and shown good safety, tolerance, and efficacy.
Here we review the actions of FGF21 … treatment for metabolic diseases via targeting FGF21. …

… we will focus on FGF21 levels in the blood of healthy, obese and … FGF21 levels, clinical
parameters associating with FGF21 … (FAP), a protease that inactivates human FGF21 in the blood. …

… An interesting aspect in the discovery of FGF21’s metabolic actions is that FGF21 was
identified in a screen for factors that increased white adipocyte glucose uptake independently of …

… FGF21-FGFR1/β-KL signaling pathway across multiple metabolic organs under metabolic
health and disease… Conversely, using genetic or pharmacological modulation, FGF21 displays …

… is increased by FGF21-transcription factor modulators, such … , FGF21 is a valuable biomarker
for metabolic diseases and … Regarding the role of FGF21 as a biomarker in CVD, more …

… However, the mechanism by which FGF21 achieves curative effects is still not known. This
… between FGF21, aging, and metabolic diseases and delineate the pharmacology of FGF21, …

… On the other hand, direct modulation of metabolism and mediation of FGF21’s cytoprotective
effects in liver, described below, likely requires agonism of FGFR2c and possibly FGFR3c. …

… the relationship between FGF21 and CVDs including coronary heart disease, myocardial …
mechanism of the cardioprotective effect of FGF21. FGF21 plays an important role in the …

… The role of FGF21 in metabolic associated diseases like diabetes mellitus had been … a
correlation between FGF21 and liver diseases. Non-alcoholic fatty liver disease (NAFLD) is the …

… factor that regulates glucose metabolism, the most consistent metabolic effects of FGF21 on
obesity and diabetes have occurred in lipid metabolism [63]. Unlike other FGFs, FGF21 is not …