RNA Sequencing Reveals the Upregulation of FOXO Signaling Pathway in Porphyromonas gingivalis Persister-Treated Human Gingival Epithelial Cells

C Wang, X Li, T Cheng, L Wang, L Jin - International Journal of Molecular …, 2022 - mdpi.com
gingivalis persisters and revealed the unforeseen perturbation of innate response in human
gingival epithelial cells (HGECs) due to these … Herein, RNA sequencing revealed how P. …

[PDF][PDF] P. gingivalis Modulates Keratinocytes Through FOXO Modulates Keratinocytes Through FOXO Transcription Factors

S Li, G Dong, A Moschidis, J Ortiz, MR Benakanakere - core.ac.uk
… In this study we challenged gingival epithelial cells with P. gingivalis with the aim of …
response to bacteria is attenuated in oral epithelial cells. In addition we found that knockdown of …

The roles of FOXO1 in periodontal homeostasis and disease

L Ren, J Yang, J Wang, X Zhou… - Journal of Immunology …, 2021 - Wiley Online Library
gingivalis in gingival epithelial cells is also mediated through the pathway involving FOXO1.
… suggest that FOXO1 comprises a component of host epithelial response to periodontal …

Epithelial responses to Porphyromonas gingivalis in the community context.

ZR Fitzsimonds - 2020 - ir.library.louisville.edu
… survival, activation of the multi-purpose transcriptional regulator FOXO1 by … in epithelial
cells, and knockdown of FOXO1 abrogates P. gingivalis-induced resistance to cell death [30]. …

An evaluation of the molecular mode of action of trans-resveratrol in the Porphyromonas gingivalis lipopolysaccharide challenged neuronal cell model

B Bahar, SK Singhrao - Molecular Biology Reports, 2021 - Springer
… In response to the P gingivalis infection that often results in a … epithelium, the PgLPS is
expected to increase the FOXO1 expression [45]. Then, a subsequent translocation of FOXO1 into …

Porphyromonas gingivalis adopts intricate and unique molecular mechanisms to survive and persist within the host: a critical update

A Chopra, SG Bhat, K Sivaraman - Journal of Oral Microbiology, 2020 - Taylor & Francis
gingivalis modulates the immune response with activation of … -catenin and Forkhead box
protein O1 (FOXO1). S. gordonii can … gingivalis to use the epithelial cells as an autophagosome …

Regulation of olfactomedin 4 by Porphyromonas gingivalis in a community context

ZR Fitzsimonds, C Liu, KS Stocke… - The ISME …, 2021 - academic.oup.com
gingivalis can activate FOXO1 signaling which increases expression of ZEB2 and initiates …
of the gingival epithelial cell pathways regulated in response to P. gingivalis alone, but which …

[HTML][HTML] FOXO1 inhibits FSL-1 regulation of integrin β6 by blocking STAT3 binding to the integrin β6 gene promoter

M Xu, J Huang, F Zhu, K Shen, F Liu… - Frontiers in Cellular and …, 2022 - frontiersin.org
response, we hypothesized that FOXO1 and STAT3 are involved in ITGB6 transcription in
epithelial cells… Sequence analysis predicted several putative transcription factor FOXO1 and …

Potential role of epithelial–mesenchymal transition induced by periodontal pathogens in oral cancer

Y Ma, Y Yu, Y Yin, L Wang, H Yang… - Journal of Cellular …, 2024 - Wiley Online Library
… carefully to determine the host cells' response to P. gin- … controls the induction of ZEB2 by
activating the FOXO1 … gingival epithelial cells and monocytes by Porphyromonas gingivalis

A bacterial tyrosine phosphatase modulates cell proliferation through targeting RGCC

C Liu, K Stocke, ZR Fitzsimonds, L Yakoumatos… - PLoS …, 2021 - journals.plos.org
gingivalis also transitions gingival epithelial cells toward EMT through Zeb2, we hypothesized
that RGCC may also control Zeb2 responses to P… involving β-catenin and FOXO1 [17]. …