… Of note, autoimmunity may also be a risk factor for cancer [30,… FEN1 somatic mutations have
been found in non-small cell … & endonuclease activities Autoimmunity, chronic inflammation, …

… Abnormal expression or mutation of FEN1 in cells can cause a series of pathological …
autoimmune diseases (systemic lupus erythematosus) and chronic inflammatory responses [68]. …

… FEN1 somatic mutations have been found in non-small cell lung carcinoma, melanoma, and
oesophageal cancers, … Fen1 mutations result in autoimmunity, chronic inflammation and …

… Knock-in of a cancer-related inactivating Fen1 mutation resulted in a high … Fen1 mutant
mouse model displayed a marked predisposition to chronic inflammation and autoimmunity (120)…

… of matched BRCA2-mutant (PEO1) and BRCA2-revertant (PEO4) ovarian cancer cell lines
… four previously described FEN1 inhibitors selectively killed the BRCA2-mutant PEO1 cells in …

… FEN1 somatic mutations have been found in non-small cell lung carcinoma, melanoma, and
oesophageal cancers, … Fen1 mutations result in autoimmunity, chronic inflammation and …

… FEN1 inhibitor hits that are suitable for further drug development. We conclude that FEN1 is
a valid target for ovarian cancer … model with a mutation in FEN1 and adenomatous polyposis …

… FEN1 inhibitor FEN1-IN-4 on breast cancer cell lines including four TNBC cell lines and
whether it is a useful therapeutic agent in breast cancer … be due to mutations in the FEN1 gene, …

… He also found FEN1 mutants and confirmed that FEN1 mutations are related to autoimmune
diseases, chronic inflammation and cancer [19]. Among the articles published by Zheng L, …

… signs of autoimmunity-induced chronic inflammation. FEN1 E160D-mutant mice have also
… by this mutation promoted the development of aneuploid cancers. Given the critical role that …