Pregnancy serum DLK1 concentrations are associated with indices of insulin resistance and secretion
CJ Petry, KA Burling, P Barker… - The Journal of …, 2021 - academic.oup.com
… critical for appropriate maternal metabolic adaptation during pregnancy (3). Thus, DLK1 gene
… of the imprinted gene regulation of maternal/fetal metabolic interactions during pregnancy. …
… of the imprinted gene regulation of maternal/fetal metabolic interactions during pregnancy. …
Circulating Delta-like homolog 1 (DLK1) at 36 weeks is correlated with birthweight and is of placental origin
TM MacDonald, SP Walker, R Hiscock, P Cannon… - Placenta, 2020 - Elsevier
… measure DLK1 in a large independent cohort of maternal blood … and assess whether DLK1
might be placental derived. … measure DLK1 in a large independent cohort of maternal plasma …
might be placental derived. … measure DLK1 in a large independent cohort of maternal plasma …
[HTML][HTML] Low maternal DLK1 levels at 26 weeks is associated with small for gestational age at birth
A Pham, D Mitanchez, A Forhan, L Perin… - Frontiers in …, 2022 - frontiersin.org
… maternal circulating DLK1 levels to be positively associated … be required for maternal
metabolic adaptations to pregnancy… , DLK1 levels are significantly lower at 36 WG for pregnant …
metabolic adaptations to pregnancy… , DLK1 levels are significantly lower at 36 WG for pregnant …
[HTML][HTML] Maternal RNA transcription in Dlk1-Dio3 domain is critical for proper development of the mouse placental vasculature
X Zhang, H He, H Yu, X Teng, Z Wang, C Li, J Li… - Communications …, 2024 - nature.com
… Here, we found that maternal RNA transcription in Dlk1-Dio3 imprinted domain is essential
… to establish a mouse model to prevent the expression of maternal RNAs in the domain. The …
… to establish a mouse model to prevent the expression of maternal RNAs in the domain. The …
DLK1: A Novel Biomarker of Placental Insufficiency in Stillbirth and Live Birth
JM Page, AA Allshouse, JE Gaffney… - American journal of …, 2022 - thieme-connect.com
… homolog 1 (DLK1) is a growth factor that is reduced in maternal sera in pregnancies with
small for gestational age neonates. We sought to determine if DLK1 is associated with stillbirth (…
small for gestational age neonates. We sought to determine if DLK1 is associated with stillbirth (…
Screening of patients born small for gestational age with the Silver-Russell syndrome phenotype for DLK1 variants
A Pham, ML Sobrier, E Giabicani… - European Journal of …, 2021 - nature.com
… Both variants were inherited from the mother of the patients, which does not favor a role in …
DLK1 is from the paternal-inherited allele. We did not identify any pathogenic variants in DLK1 …
DLK1 is from the paternal-inherited allele. We did not identify any pathogenic variants in DLK1 …
Delta-like 1 homolog genetics and its emerging role in human puberty
… The high expression of DLK1 in the fetus appears to induce maternal metabolic adaptations
that benefit nutrient delivery and leads to rapid starvation, as shown in murine models by …
that benefit nutrient delivery and leads to rapid starvation, as shown in murine models by …
Genome-wide DNA methylation, imprinting, and gene expression in human placentas derived from Assisted Reproductive Technology
P Auvinen, J Vehviläinen, K Rämö, I Laukkanen… - medRxiv, 2023 - medrxiv.org
… showed in mouse that both Dlk1 516 expression in maternal tissues and … DLK1 derived
from the fetus are necessary for 517 appropriate maternal metabolic adaptations to pregnancy by …
from the fetus are necessary for 517 appropriate maternal metabolic adaptations to pregnancy by …
[HTML][HTML] Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice
… To verify that DNA methylation was correctly maintained in these reporter mice we
performed bisulphite analysis across the Dlk1 sDMR, IG-DMR and Gtl2 sDMR, comparing Dlk1-…
performed bisulphite analysis across the Dlk1 sDMR, IG-DMR and Gtl2 sDMR, comparing Dlk1-…
[HTML][HTML] Dlk1 maintains adult mice long-term HSCs by activating Notch signaling to restrict mitochondrial metabolism
D Huang, Y Han, T Tang, L Yang, P Jiang… - … Hematology & Oncology, 2023 - Springer
… of Dlk1, we specifically knockout Dlk1 in HSCs of mice by Mx1-Cre/loxP system. We found
that Dlk1 … However, Dlk1-deficient LT-HSCs exhibited a remarkable decrease in the long-term …
that Dlk1 … However, Dlk1-deficient LT-HSCs exhibited a remarkable decrease in the long-term …