… critical for appropriate maternal metabolic adaptation during pregnancy (3). Thus, DLK1 gene
… of the imprinted gene regulation of maternal/fetal metabolic interactions during pregnancy. …

… measure DLK1 in a large independent cohort of maternal blood … and assess whether DLK1
might be placental derived. … measure DLK1 in a large independent cohort of maternal plasma …

… maternal circulating DLK1 levels to be positively associated … be required for maternal
metabolic adaptations to pregnancy… , DLK1 levels are significantly lower at 36 WG for pregnant …

… Here, we found that maternal RNA transcription in Dlk1-Dio3 imprinted domain is essential
… to establish a mouse model to prevent the expression of maternal RNAs in the domain. The …

… homolog 1 (DLK1) is a growth factor that is reduced in maternal sera in pregnancies with
small for gestational age neonates. We sought to determine if DLK1 is associated with stillbirth (…

… Both variants were inherited from the mother of the patients, which does not favor a role in …
DLK1 is from the paternal-inherited allele. We did not identify any pathogenic variants in DLK1 …

… The high expression of DLK1 in the fetus appears to induce maternal metabolic adaptations
that benefit nutrient delivery and leads to rapid starvation, as shown in murine models by …

… showed in mouse that both Dlk1 516 expression in maternal tissues and … DLK1 derived
from the fetus are necessary for 517 appropriate maternal metabolic adaptations to pregnancy by …

… To verify that DNA methylation was correctly maintained in these reporter mice we
performed bisulphite analysis across the Dlk1 sDMR, IG-DMR and Gtl2 sDMR, comparing Dlk1-…

… of Dlk1, we specifically knockout Dlk1 in HSCs of mice by Mx1-Cre/loxP system. We found
that Dlk1 … However, Dlk1-deficient LT-HSCs exhibited a remarkable decrease in the long-term …