Metabolism and pharmacological activities of the natural health-benefiting compound diosmin

Y Zheng, R Zhang, W Shi, L Li, H Liu, Z Chen, L Wu - Food & function, 2020 - pubs.rsc.org
diosmetin induces apoptosis in renal carcinoma ACHN cells … of flavonoids have been
linked to the inhibition of ATP … , diosmetin may completely reverse the ATP-depleting effects

[HTML][HTML] Comprehensive review on therapeutic and phytochemical exploration of diosmetin: A promising moiety

M Garg, SK Chaudhary, A Goyal, P Sarup, S Kumari… - Phytomedicine …, 2022 - Elsevier
… acids and flavonoids as its active constituents including diosmetin-6-o-… The diosmetin was
found to protect against renal injury in … Diosmetin was able to amplify the ATP production and …

Diosmetin as a promising natural therapeutic agent: In vivo, in vitro mechanisms, and clinical studies

Z Sun, K Liu, C Liang, L Wen, J Wu… - Phytotherapy …, 2024 - Wiley Online Library
Diosmetin (DIO, Figure 2) is a flavonoid compound that can be … the MAPK pathway helps
safeguard cells during oxidative stress. … DIO increased the ATP levels in MDCK kidney cells and …

[HTML][HTML] … and diosmetin inhibited the HSP70/TLR4/NF-κB p65/NLRP3 signaling pathways and switched macrophage to M2 phenotype in a rat model of acute kidney …

HM Saad, E Elekhnawy, MA Shaldam… - Biomedicine & …, 2024 - Elsevier
… One of the main flavonoid compounds recently extracted … resulted in a substantial rise in the
renal index by 224% relative … Time-kill curve helps us to understand the possible interactions …

… THE MOLECULAR MECHANISMS UNDERLYING THE ANTI-CANCER ACTIVITIES OF DIOSMETIN IN COLORECTAL CANCER CELLS: AN IN VITRO STUDY

SN AHMED - 2022 - qspace.qu.edu.qa
… or the tissue lining of different organs such as the liver, kidneys… OXPHOS), which are required
for adenosine triphosphate (ATP) … Anticancer effects of the flavonoid diosmetin on cell cycle …

Overview and Potential Benefits of Flavonoids in Diabetes

S Kabra, AP Singh, V Kesharwani… - Advances in Flavonoids …, 2024 - taylorfrancis.com
… of high cellular energy demand the increase in AMP/ATP is … therapy helps to lower the
blood sugar level that is increased … Prophylactic effect of baicalein against renal dysfunction in …

Inhibition of TGF-β Signaling in Gliomas by the Flavonoid Diosmetin Isolated from Dracocephalum peregrinum L.

Y Yan, X Liu, J Gao, Y Wu, Y Li - Molecules, 2020 - mdpi.com
… Conclusion: The results of this study suggest that diosmetin suppresses the growth of glioma
cells in vitro and in vivo, possibly by activating E-cadherin expression and inhibiting the TGF…

Citrus flavonoids and the mitochondria

C Panneerselvam, DB Vadivel… - … Physiology and Vegetal …, 2021 - Elsevier
… the dietary flavonoids in virtue of their increasing therapeutic … cellular machinery. One
of the foremost function of the mitochondria is the production of adenosine triphosphate (ATP) …

An up-to-date review on citrus flavonoids: chemistry and benefits in health and diseases

OM Ahmed, SF AbouZid, NA Ahmed… - Current …, 2021 - ingentaconnect.com
… disorders as well as liver, kidney and heart diseases. The … Luteolin and diosmetin are the
most present flavones in the … include (1) cell survival inhibition by binding ATP to the PI3K …

An Overview of Dietary Flavonoids as a Nutraceutical Nanoformulation Approach to Life-threatening Diseases

S Singh, A Ahuja, H Sharma… - Current Pharmaceutical …, 2023 - ingentaconnect.com
… of flavonoids to lower oxidative stress and raise NO levels is … In addition, this flavonoid
helps regulate cell membrane … bioactive molecules with this ATP at enzymatic catalytic sites. …