… to support chemopreventive strategies in prostate cancer (… healthy men significantly
increased the risk of prostate cancer.… flutamide and nilutamide. These are used in castrate-sensitive …

… Men with localized or regionally spread prostate cancer have … pathway and transforms prostate
epithelial cells [155]. … ) for prostate cancer treatment included bicalutamide, flutamide, and …

… such as bicalutamide, nilutamide, and flutamide, were also developed; these anti-androgens …
the first AR NTD inhibitor tested in a Phase 1 study in men with CRPC. The drug was well-…

… earlier steroidal anti-androgen flutamide, is more commonly … -initiating population of prostate
epithelial cells but upregulated … the FDA in a chemoprevention role for prostate cancer, and …

… tea consumption and cancer chemoprevention in men diagnosed with prostate cancer [1],
[2]… commonly dysregulated in the development of prostate cancer, and could potentially act in …

… potential as PCa chemopreventive and therapeutic agents, although some studies have
reported the possibility of 5ARIs increasing the risk of high-grade PCa in men. Currently, the 4-…

… in prostate epithelial cells. The expression of ERα in … Flutamide, enzalutamide, and
apalutamide are examples of … In addition, a study has shown that male patients with hormone-…

… The evidence for the role of AIs as chemopreventive agents … of prostate cancers are derived
from prostate epithelial cells, … non-steroidal (bicalutimide, flutamide). Non-steroidal agents …

… Randomized, double-blind, placebo-controlled phase III trial comparing docetaxel and
prednisone with or without bevacizumab in men with metastatic castrationresistant prostate cancer…

… male patients were all prostate cancer patients and most female patients had breast cancer.
… tumours was examined in a randomised, double-blind, placebo-controlled study [78]. The …