… modeling (PBBM) during clinical development to understand the impact of food and gastric
pH changes on absorption of … reasonable permeability but strongly pH-dependent solubility. …

… is triggered by food consumption (Figure 2). … gastric and intestinal system can impact oral
drug absorption, including fluctuations in the gastrointestinal pH, an increased gastrointestinal …

… -dependent), drug and formulation properties, or food-drug interactions. Clinical evidence …
drug pharmacokinetic variability is mounting: eg gastric pH and emptying time, small intestinal …

… of food on various elements in drug absorption, including change in stomach pH and gastric
… the performance of PBPK models to correctly predict the lack of pH-dependent DDI potential …

… medication. This review provides an overview of GI tract properties in special populations
compared to healthy adults and discusses how drug absorption is affected by these conditions. …

… fasted conditions or taken with a meal to maximize drug absorption. … Models predicted
either no food effect or negative food effect, depending on the software used and the stomach pH …

… critical to oral drug absorption. … oral absorption landscape: (1) specific patient populations,
(2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food…

… Food intake stimulates GI secretions including hormones … lower gastric pH, delay stomach
emptying and increase GI transit … stomach pH within minutes to hours, diet itself can change GI …

… an ARA may reduce drug absorption and systemic exposure, … of reduced absorption under
high stomach pH conditions. To … with food, but it is not known whether food intake will mitigate …

… food and proton pump inhibitor effects on oral drug exposure. … SGF at pH 1.6 is higher than
the value reported at pH 1.1.16 … on predicting the oral drug absorption of a drug candidate in …