… This paper reviewed the progress of preclinical and clinical research on clinically … of
hypoxia inducible factors (HIFs) and their regulatory hydroxylases, three HIF prolyl hydroxylase …

… is inhibited via substrate (molecular oxygen) depletion during hypoxia, allowing the HIF-α
subunits to escape proline hydroxylation-… in clinical studies, FG-4592/roxadustat, GSK1278863/…

… Hypoxia-inducible factor (HIF) is crucial to erythropoietin production, as a result, prolyl
hydroxylase domain (PHD) enzyme inhibitors have … They can be administered orally, which is a …

… Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-… HIF-PHIs are available as
oral agents whose primary … Recent studies have also indicated the involvement of HIF3α …

… Fourweek studies of oral hypoxia-inducible factorprolyl hydroxylase inhibitor GSK1278863
… Iron regulation by Molidustat, a daily oral hypoxiainducible factor prolyl hydroxylase inhibitor, …

… The hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) is a new class of oral drugs
… Studies also suggested that reduced diferric transferrin as in iron deficiency or increased …

… ng/ml and transferrin saturation < 20%, yet the optimal ranges of these parameters and
effective routes of iron administration (oral or intravenous) need to be explored in future studies. …

… studies extensively investigated the mechanisms involved in the body’s response to hypoxia
and led to the discovery of the hypoxia-inducible factor (HIF) … are a new class of oral drugs …

… Twenty studies with 14,737 participants were included in the meta-analysis, which … anemia
in CKD patients undergoing dialysis, 3) used oral intake of HIF-PHIs (Roxadustat, Daprodustat…

… Studies have shown that oral iron supplementation is associated with an acute increase in …
Novel hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) have been associated …